Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5567086..5567711 Replicon chromosome
Accession NZ_CP116903
Organism Klebsiella pneumoniae strain KP2722

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag PO783_RS27555 Protein ID WP_002882817.1
Coordinates 5567086..5567469 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag PO783_RS27560 Protein ID WP_004150355.1
Coordinates 5567469..5567711 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PO783_RS27540 (PO783_27540) 5564452..5565354 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
PO783_RS27545 (PO783_27545) 5565351..5565986 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
PO783_RS27550 (PO783_27550) 5565983..5566912 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
PO783_RS27555 (PO783_27555) 5567086..5567469 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
PO783_RS27560 (PO783_27560) 5567469..5567711 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
PO783_RS27565 (PO783_27565) 5567916..5568833 + 918 WP_002882812.1 alpha/beta hydrolase -
PO783_RS27570 (PO783_27570) 5568847..5569788 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
PO783_RS27575 (PO783_27575) 5569833..5570270 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
PO783_RS27580 (PO783_27580) 5570267..5571127 - 861 WP_002882807.1 virulence factor BrkB family protein -
PO783_RS27585 (PO783_27585) 5571121..5571720 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T269351 WP_002882817.1 NZ_CP116903:c5567469-5567086 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT269351 WP_004150355.1 NZ_CP116903:c5567711-5567469 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References