Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5241835..5243516 Replicon chromosome
Accession NZ_CP116903
Organism Klebsiella pneumoniae strain KP2722

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag PO783_RS26040 Protein ID WP_002885155.1
Coordinates 5241835..5242752 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag PO783_RS26045 Protein ID WP_004151732.1
Coordinates 5242758..5243516 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PO783_RS26020 (PO783_26020) 5237141..5238661 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
PO783_RS26025 (PO783_26025) 5238658..5239656 + 999 WP_002885172.1 ribose ABC transporter permease -
PO783_RS26030 (PO783_26030) 5239687..5240628 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
PO783_RS26035 (PO783_26035) 5240703..5241710 + 1008 WP_004151731.1 carbohydrate kinase family protein -
PO783_RS26040 (PO783_26040) 5241835..5242752 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
PO783_RS26045 (PO783_26045) 5242758..5243516 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
PO783_RS26050 (PO783_26050) 5243602..5244330 - 729 WP_002885152.1 response regulator transcription factor -
PO783_RS26055 (PO783_26055) 5244603..5246750 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
PO783_RS26060 (PO783_26060) 5246980..5247666 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T269350 WP_002885155.1 NZ_CP116903:c5242752-5241835 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT269350 WP_004151732.1 NZ_CP116903:c5243516-5242758 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References