Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3179406..3180093 Replicon chromosome
Accession NC_017524
Organism Mycobacterium tuberculosis CTRI-2

Toxin (Protein)


Gene name vapC Uniprot ID P65044
Locus tag MTCTRI2_RS15150 Protein ID WP_003414624.1
Coordinates 3179650..3180093 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TFH0
Locus tag MTCTRI2_RS15145 Protein ID WP_003414620.1
Coordinates 3179406..3179663 (+) Length 86 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTCTRI2_RS15125 3174726..3175580 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
MTCTRI2_RS15130 3175636..3176799 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
MTCTRI2_RS15135 3176816..3178030 - 1215 WP_003899518.1 zinc metalloprotease Rip -
MTCTRI2_RS15140 3178038..3179279 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
MTCTRI2_RS15145 3179406..3179663 + 258 WP_003414620.1 ribbon-helix-helix domain-containing protein Antitoxin
MTCTRI2_RS15150 3179650..3180093 + 444 WP_003414624.1 type II toxin-antitoxin system VapC family toxin Toxin
MTCTRI2_RS15155 3180173..3180835 + 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
MTCTRI2_RS15160 3180931..3181122 + 192 WP_003414632.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MTCTRI2_RS15165 3181454..3183202 + 1749 WP_003912869.1 cytochrome c biogenesis protein DipZ -
MTCTRI2_RS15170 3183298..3183879 + 582 WP_003414644.1 fasciclin domain-containing protein -
MTCTRI2_RS15175 3183979..3184245 + 267 WP_015456449.1 DUF2631 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-142)

Antitoxin

(2-38)


Sequences


Toxin        


Download         Length: 148 a.a.        Molecular weight: 16595.72 Da        Isoelectric Point: 6.4890

>T26935 WP_003414624.1 NC_017524:3179650-3180093 [Mycobacterium tuberculosis CTRI-2]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

>T26935 NC_017524:3179650-3180093 [Mycobacterium tuberculosis CTRI-2]
ATGCTGTGCGTTGATGTCAACGTGCTCGTTTACGCGCATCGGGCAGACCTACGGGAGCACGCGGACTATCGGGGTTTGCT
TGAGCGGCTGGCCAACGATGACGAGCCGCTGGGTCTACCAGATAGCGTGCTCGCCGGCTTCATCCGGGTGGTTACCAACC
GCCGCGTCTTCACCGAGCCGACGAGCCCACAGGACGCATGGCAGGCAGTCGACGCCCTACTCGCGGCACCCGCAGCCATG
CGACTTCGGCCTGGCGAGCGCCACTGGATGGCCTTTCGGCAGTTAGCGTCCGATGTTGATGCGAACGGCAACGACATTGC
GGACGCGCACCTGGCCGCCTACGCGCTAGAGAACAACGCAACCTGGTTGAGCGCCGACCGCGGCTTTGCCCGTTTCCGTC
GACTGCGCTGGCGTCATCCGTTGGACGGTCAGACCCATCTATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9013.22 Da        Isoelectric Point: 10.8344

>AT26935 WP_003414620.1 NC_017524:3179406-3179663 [Mycobacterium tuberculosis CTRI-2]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Download         Length: 258 bp

>AT26935 NC_017524:3179406-3179663 [Mycobacterium tuberculosis CTRI-2]
GTGCGCACGACGATCCGTATCGATGACGAGCTGTACCGCGAGGTGAAAGCAAAGGCCGCTCGTTCCGGGCGTACCGTGGC
CGCGGTTCTTGAAGATGCGGTGCGGCGTGGTCTCAACCCGCCTAAGCCGCAGGCCGCCGGCCGTTATCGAGTCCAGCCGT
CGGGTAAGGGCGGCCTGCGGCCCGGTGTCGATCTATCGTCCAACGCCGCACTTGCCGAAGCGATGAACGACGGCGTGTCG
GTCGATGCTGTGCGTTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7VWO


Antitoxin

Source ID Structure
PDB 7VWO
AlphaFold DB G0TFH0

References