Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-RelB |
Location | 5084345..5084861 | Replicon | chromosome |
Accession | NZ_CP116903 | ||
Organism | Klebsiella pneumoniae strain KP2722 |
Toxin (Protein)
Gene name | relE | Uniprot ID | J2XDK6 |
Locus tag | PO783_RS25235 | Protein ID | WP_002886902.1 |
Coordinates | 5084345..5084629 (-) | Length | 95 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | R4Y888 |
Locus tag | PO783_RS25240 | Protein ID | WP_002886901.1 |
Coordinates | 5084619..5084861 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
PO783_RS25210 (PO783_25210) | 5079829..5080092 | - | 264 | WP_004152271.1 | PTS sugar transporter subunit IIB | - |
PO783_RS25215 (PO783_25215) | 5080222..5080395 | + | 174 | WP_002886906.1 | hypothetical protein | - |
PO783_RS25220 (PO783_25220) | 5080398..5081141 | + | 744 | WP_002886905.1 | MurR/RpiR family transcriptional regulator | - |
PO783_RS25225 (PO783_25225) | 5081498..5083636 | + | 2139 | WP_002886904.1 | anaerobic ribonucleoside-triphosphate reductase | - |
PO783_RS25230 (PO783_25230) | 5083877..5084341 | + | 465 | WP_002886903.1 | anaerobic ribonucleoside-triphosphate reductase-activating protein | - |
PO783_RS25235 (PO783_25235) | 5084345..5084629 | - | 285 | WP_002886902.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
PO783_RS25240 (PO783_25240) | 5084619..5084861 | - | 243 | WP_002886901.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
PO783_RS25245 (PO783_25245) | 5084939..5086849 | - | 1911 | WP_004152270.1 | PRD domain-containing protein | - |
PO783_RS25250 (PO783_25250) | 5086872..5088026 | - | 1155 | WP_002886900.1 | lactonase family protein | - |
PO783_RS25255 (PO783_25255) | 5088092..5088832 | - | 741 | WP_002886899.1 | KDGP aldolase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 11125.95 Da Isoelectric Point: 10.3787
>T269349 WP_002886902.1 NZ_CP116903:c5084629-5084345 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL
Download Length: 285 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GMH2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GLP0 |