Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 5084345..5084861 Replicon chromosome
Accession NZ_CP116903
Organism Klebsiella pneumoniae strain KP2722

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag PO783_RS25235 Protein ID WP_002886902.1
Coordinates 5084345..5084629 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag PO783_RS25240 Protein ID WP_002886901.1
Coordinates 5084619..5084861 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PO783_RS25210 (PO783_25210) 5079829..5080092 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
PO783_RS25215 (PO783_25215) 5080222..5080395 + 174 WP_002886906.1 hypothetical protein -
PO783_RS25220 (PO783_25220) 5080398..5081141 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
PO783_RS25225 (PO783_25225) 5081498..5083636 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
PO783_RS25230 (PO783_25230) 5083877..5084341 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PO783_RS25235 (PO783_25235) 5084345..5084629 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PO783_RS25240 (PO783_25240) 5084619..5084861 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PO783_RS25245 (PO783_25245) 5084939..5086849 - 1911 WP_004152270.1 PRD domain-containing protein -
PO783_RS25250 (PO783_25250) 5086872..5088026 - 1155 WP_002886900.1 lactonase family protein -
PO783_RS25255 (PO783_25255) 5088092..5088832 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T269349 WP_002886902.1 NZ_CP116903:c5084629-5084345 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT269349 WP_002886901.1 NZ_CP116903:c5084861-5084619 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References