Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2745501..2746126 Replicon chromosome
Accession NZ_CP116900
Organism Escherichia coli strain XH2172

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PH219_RS13220 Protein ID WP_000911330.1
Coordinates 2745728..2746126 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag PH219_RS13215 Protein ID WP_000450524.1
Coordinates 2745501..2745728 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PH219_RS13190 (2741304) 2741304..2741774 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
PH219_RS13195 (2741774) 2741774..2742346 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
PH219_RS13200 (2742492) 2742492..2743370 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
PH219_RS13205 (2743387) 2743387..2744421 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
PH219_RS13210 (2744634) 2744634..2745347 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
PH219_RS13215 (2745501) 2745501..2745728 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
PH219_RS13220 (2745728) 2745728..2746126 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
PH219_RS13225 (2746273) 2746273..2747136 + 864 WP_001267507.1 neutral zinc metallopeptidase -
PH219_RS13230 (2747151) 2747151..2749166 + 2016 WP_000829323.1 tRNA cytosine(34) acetyltransferase TmcA -
PH219_RS13235 (2749240) 2749240..2749581 + 342 Protein_2571 esterase -
PH219_RS13240 (2749663) 2749663..2750409 - 747 WP_053906593.1 IS21-like element ISEc12 family helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T269320 WP_000911330.1 NZ_CP116900:2745728-2746126 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT269320 WP_000450524.1 NZ_CP116900:2745501-2745728 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References