Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2304584..2305238 Replicon chromosome
Accession NZ_CP116900
Organism Escherichia coli strain XH2172

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag PH219_RS11115 Protein ID WP_000244777.1
Coordinates 2304831..2305238 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PH219_RS11110 Protein ID WP_000354046.1
Coordinates 2304584..2304850 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PH219_RS11085 (2299872) 2299872..2300615 + 744 Protein_2155 SDR family oxidoreductase -
PH219_RS11090 (2300672) 2300672..2302105 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
PH219_RS11095 (2302150) 2302150..2302461 + 312 WP_001679467.1 N(4)-acetylcytidine aminohydrolase -
PH219_RS11100 (2302625) 2302625..2303284 + 660 WP_000250274.1 hemolysin III family protein -
PH219_RS11105 (2303361) 2303361..2304341 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
PH219_RS11110 (2304584) 2304584..2304850 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PH219_RS11115 (2304831) 2304831..2305238 + 408 WP_000244777.1 protein YgfX Toxin
PH219_RS11120 (2305278) 2305278..2305799 - 522 WP_001055874.1 flavodoxin FldB -
PH219_RS11125 (2305911) 2305911..2306807 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PH219_RS11130 (2306832) 2306832..2307542 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PH219_RS11135 (2307548) 2307548..2309281 + 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T269317 WP_000244777.1 NZ_CP116900:2304831-2305238 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT269317 WP_000354046.1 NZ_CP116900:2304584-2304850 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References