Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 1741265..1742065 Replicon chromosome
Accession NZ_CP116900
Organism Escherichia coli strain XH2172

Toxin (Protein)


Gene name ataT Uniprot ID F4NNI0
Locus tag PH219_RS08260 Protein ID WP_000342449.1
Coordinates 1741538..1742065 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4NNI1
Locus tag PH219_RS08255 Protein ID WP_001277108.1
Coordinates 1741265..1741531 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PH219_RS08235 (1736922) 1736922..1737590 + 669 WP_000617723.1 cell division ATP-binding protein FtsE -
PH219_RS08240 (1737583) 1737583..1738641 + 1059 WP_001042003.1 permease-like cell division protein FtsX -
PH219_RS08245 (1738886) 1738886..1739740 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
PH219_RS08250 (1740012) 1740012..1741115 + 1104 WP_001350438.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
PH219_RS08255 (1741265) 1741265..1741531 + 267 WP_001277108.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
PH219_RS08260 (1741538) 1741538..1742065 + 528 WP_000342449.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
PH219_RS08265 (1742062) 1742062..1742445 - 384 WP_000778781.1 aspartate 1-decarboxylase autocleavage activator PanM -
PH219_RS08270 (1742869) 1742869..1743978 + 1110 WP_000827696.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
PH219_RS08275 (1744026) 1744026..1744952 + 927 WP_000003004.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
PH219_RS08280 (1744949) 1744949..1746226 + 1278 WP_000803799.1 branched chain amino acid ABC transporter permease LivM -
PH219_RS08285 (1746223) 1746223..1746990 + 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19691.70 Da        Isoelectric Point: 7.7457

>T269314 WP_000342449.1 NZ_CP116900:1741538-1742065 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLCGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNKKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9910.31 Da        Isoelectric Point: 10.0863

>AT269314 WP_001277108.1 NZ_CP116900:1741265-1741531 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRVILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CLZ4

Antitoxin

Source ID Structure
PDB 6GTS
PDB 6AJN
PDB 6GTQ
PDB 6GTO
PDB 6GTR
PDB 6AJM
AlphaFold DB A0A829CN24

References