Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1719974..1720560 Replicon chromosome
Accession NZ_CP116900
Organism Escherichia coli strain XH2172

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag PH219_RS08135 Protein ID WP_042014162.1
Coordinates 1719974..1720204 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag PH219_RS08140 Protein ID WP_000593555.1
Coordinates 1720201..1720560 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PH219_RS08125 (1716011) 1716011..1718746 + 2736 WP_000149132.1 ribosome-associated ATPase/putative transporter RbbA -
PH219_RS08130 (1718746) 1718746..1719870 + 1125 WP_001314210.1 ABC transporter permease -
PH219_RS08135 (1719974) 1719974..1720204 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
PH219_RS08140 (1720201) 1720201..1720560 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PH219_RS08145 (1720680) 1720680..1721081 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
PH219_RS08150 (1721087) 1721087..1721893 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
PH219_RS08155 (1721890) 1721890..1722654 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
PH219_RS08160 (1722654) 1722654..1723487 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
PH219_RS08165 (1723484) 1723484..1724428 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T269313 WP_042014162.1 NZ_CP116900:1719974-1720204 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT269313 WP_000593555.1 NZ_CP116900:1720201-1720560 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References