Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 883842..884339 Replicon chromosome
Accession NZ_CP116900
Organism Escherichia coli strain XH2172

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag PH219_RS04235 Protein ID WP_001173343.1
Coordinates 883842..884015 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID J7RC38
Locus tag PH219_RS04240 Protein ID WP_001425728.1
Coordinates 884043..884339 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PH219_RS04225 (880512) 880512..881969 + 1458 WP_000856841.1 dipeptide/tripeptide permease DtpC -
PH219_RS04230 (882206) 882206..883723 + 1518 WP_001295074.1 lysine--tRNA ligase -
PH219_RS04235 (883842) 883842..884015 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
PH219_RS04240 (884043) 884043..884339 - 297 WP_001425728.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
PH219_RS04245 (884566) 884566..884838 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
PH219_RS04250 (884850) 884850..885080 - 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
PH219_RS04255 (885261) 885261..886892 + 1632 WP_001216487.1 sensor histidine kinase -
PH219_RS04260 (886889) 886889..887608 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T269311 WP_001173343.1 NZ_CP116900:c884015-883842 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11466.99 Da        Isoelectric Point: 4.2544

>AT269311 WP_001425728.1 NZ_CP116900:c884339-884043 [Escherichia coli]
MEGKNKFNTYVVSFNYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB J7RC38

References