Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 3103868..3104438 | Replicon | chromosome |
Accession | NC_017524 | ||
Organism | Mycobacterium tuberculosis CTRI-2 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | P71650 |
Locus tag | MTCTRI2_RS14750 | Protein ID | WP_003414166.1 |
Coordinates | 3103868..3104224 (-) | Length | 119 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | P0CL61 |
Locus tag | MTCTRI2_RS14755 | Protein ID | WP_003901465.1 |
Coordinates | 3104208..3104438 (-) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MTCTRI2_RS14730 | 3099320..3101008 | - | 1689 | WP_003414155.1 | alpha/beta hydrolase family protein | - |
MTCTRI2_RS14735 | 3101012..3101338 | - | 327 | WP_003414157.1 | hypothetical protein | - |
MTCTRI2_RS14740 | 3101511..3102098 | + | 588 | WP_003914429.1 | DUF3558 family protein | - |
MTCTRI2_RS14745 | 3102117..3103766 | + | 1650 | WP_003899485.1 | CocE/NonD family hydrolase | - |
MTCTRI2_RS14750 | 3103868..3104224 | - | 357 | WP_003414166.1 | type II toxin-antitoxin system toxin endoribonuclease MazF9 | Toxin |
MTCTRI2_RS14755 | 3104208..3104438 | - | 231 | WP_003901465.1 | antitoxin MazE | Antitoxin |
MTCTRI2_RS14760 | 3104481..3105524 | - | 1044 | WP_003414172.1 | DUF2293 domain-containing protein | - |
MTCTRI2_RS22195 | 3105715..3105990 | + | 276 | WP_003911993.1 | DUF1778 domain-containing protein | - |
MTCTRI2_RS22540 | 3106166..3106420 | - | 255 | WP_003917684.1 | hypothetical protein | - |
MTCTRI2_RS14775 | 3106568..3106972 | + | 405 | WP_009938577.1 | hypothetical protein | - |
MTCTRI2_RS14780 | 3106969..3107160 | + | 192 | WP_003414184.1 | hypothetical protein | - |
MTCTRI2_RS14785 | 3107224..3108513 | + | 1290 | Protein_2897 | transposase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 3093903..3118719 | 24816 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 12858.73 Da Isoelectric Point: 9.1962
>T26931 WP_003414166.1 NC_017524:c3104224-3103868 [Mycobacterium tuberculosis CTRI-2]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS
Download Length: 357 bp
>T26931 NC_017524:c3104224-3103868 [Mycobacterium tuberculosis CTRI-2]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG
Antitoxin
Download Length: 77 a.a. Molecular weight: 8231.01 Da Isoelectric Point: 4.1809
>AT26931 WP_003901465.1 NC_017524:c3104438-3104208 [Mycobacterium tuberculosis CTRI-2]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR
Download Length: 231 bp
>AT26931 NC_017524:c3104438-3104208 [Mycobacterium tuberculosis CTRI-2]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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