Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2305579..2306554 Replicon chromosome
Accession NZ_CP116892
Organism Bacillus anthracis strain AN18-416_2

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag PP185_RS12095 Protein ID WP_002036394.1
Coordinates 2305579..2306316 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag PP185_RS12100 Protein ID WP_000588712.1
Coordinates 2306429..2306554 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PP185_RS12075 (PP185_12075) 2301307..2302089 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
PP185_RS12080 (PP185_12080) 2302211..2303896 - 1686 WP_014654562.1 alpha-keto acid decarboxylase family protein -
PP185_RS12085 (PP185_12085) 2304003..2304485 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
PP185_RS12090 (PP185_12090) 2304653..2305390 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
PP185_RS12095 (PP185_12095) 2305579..2306316 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
PP185_RS12100 (PP185_12100) 2306429..2306554 + 126 WP_000588712.1 hypothetical protein Antitoxin
PP185_RS12105 (PP185_12105) 2306577..2306806 + 230 Protein_2323 stage II sporulation protein SB -
PP185_RS12110 (PP185_12110) 2306843..2307028 - 186 WP_002036392.1 hypothetical protein -
PP185_RS12115 (PP185_12115) 2307400..2307636 - 237 WP_001021688.1 hypothetical protein -
PP185_RS12120 (PP185_12120) 2307773..2307898 + 126 WP_000694311.1 hypothetical protein -
PP185_RS12125 (PP185_12125) 2307975..2308151 + 177 WP_000808045.1 stage II sporulation protein SB -
PP185_RS12130 (PP185_12130) 2308295..2309764 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
PP185_RS12135 (PP185_12135) 2310328..2310798 - 471 WP_000670597.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T269307 WP_002036394.1 NZ_CP116892:2305579-2306316 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT269307 WP_000588712.1 NZ_CP116892:2306429-2306554 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References