269305

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2305634..2306609 Replicon chromosome
Accession NZ_CP116889
Organism Bacillus anthracis strain AN17-384_2

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag PP184_RS12080 Protein ID WP_002036394.1
Coordinates 2305634..2306371 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag PP184_RS12085 Protein ID WP_000588712.1
Coordinates 2306484..2306609 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PP184_RS12060 (PP184_12060) 2301362..2302144 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
PP184_RS12065 (PP184_12065) 2302266..2303951 - 1686 WP_014654562.1 alpha-keto acid decarboxylase family protein -
PP184_RS12070 (PP184_12070) 2304058..2304540 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
PP184_RS12075 (PP184_12075) 2304708..2305445 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
PP184_RS12080 (PP184_12080) 2305634..2306371 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
PP184_RS12085 (PP184_12085) 2306484..2306609 + 126 WP_000588712.1 hypothetical protein Antitoxin
PP184_RS12090 (PP184_12090) 2306632..2306861 + 230 Protein_2320 stage II sporulation protein SB -
PP184_RS12095 (PP184_12095) 2306898..2307083 - 186 WP_002036392.1 hypothetical protein -
PP184_RS12100 (PP184_12100) 2307455..2307691 - 237 WP_001021688.1 hypothetical protein -
PP184_RS12105 (PP184_12105) 2307828..2307953 + 126 WP_000694311.1 hypothetical protein -
PP184_RS12110 (PP184_12110) 2308030..2308206 + 177 WP_000808045.1 stage II sporulation protein SB -
PP184_RS12115 (PP184_12115) 2308350..2309819 + 1470 WP_278068831.1 beta-Ala-His dipeptidase -
PP184_RS12120 (PP184_12120) 2310383..2310853 - 471 WP_000670597.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T269305 WP_002036394.1 NZ_CP116889:2305634-2306371 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT269305 WP_000588712.1 NZ_CP116889:2306484-2306609 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References