Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 870440..871128 Replicon chromosome
Accession NZ_CP116886
Organism Thermococcus kodakarensis strain TS901

Toxin (Protein)


Gene name vapC Uniprot ID Q5JIF0
Locus tag POG21_RS05060 Protein ID WP_011249949.1
Coordinates 870721..871128 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag POG21_RS05055 Protein ID WP_232500621.1
Coordinates 870440..870724 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
POG21_RS05025 (POG21_05025) 866090..867829 + 1740 WP_011249942.1 carbon starvation protein A -
POG21_RS05030 (POG21_05030) 867870..868154 + 285 WP_011249943.1 hypothetical protein -
POG21_RS05035 (POG21_05035) 868166..868447 + 282 WP_011249944.1 hypothetical protein -
POG21_RS05040 (POG21_05040) 868458..869453 + 996 WP_011249945.1 ArsA family ATPase -
POG21_RS05045 (POG21_05045) 869443..869727 + 285 WP_011249946.1 iron-sulfur cluster assembly protein -
POG21_RS05050 (POG21_05050) 869729..870382 + 654 WP_011249947.1 hypothetical protein -
POG21_RS05055 (POG21_05055) 870440..870724 + 285 WP_232500621.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
POG21_RS05060 (POG21_05060) 870721..871128 + 408 WP_011249949.1 type II toxin-antitoxin system VapC family toxin Toxin
POG21_RS05065 (POG21_05065) 871131..871913 + 783 WP_011249950.1 alpha/beta hydrolase -
POG21_RS05070 (POG21_05070) 872314..872547 + 234 WP_011249951.1 hypothetical protein -
POG21_RS05075 (POG21_05075) 872650..873447 + 798 WP_048053699.1 hypothetical protein -
POG21_RS05080 (POG21_05080) 873444..874463 - 1020 WP_011249953.1 adenylosuccinate synthetase -
POG21_RS05085 (POG21_05085) 874579..874842 + 264 WP_143598683.1 hypothetical protein -
POG21_RS05090 (POG21_05090) 874878..875804 + 927 WP_011249955.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-127)

Antitoxin

SpoVT-AbrB domain

(10-49)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15693.00 Da        Isoelectric Point: 4.4082

>T269302 WP_011249949.1 NZ_CP116886:870721-871128 [Thermococcus kodakarensis]
MRLLIDTNLFVYLNANIDDELAERLDRFYAELVRENEAYTNVLVLDELIHVSKRKYGVSYPETISFIEDVVLPAVRVLPI
TFEDYLTAKEIILKYHLRPSDALHAATIQNNGLQAIVSEDEDFDKLPIKRLWLEV

Download         Length: 408 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10645.46 Da        Isoelectric Point: 8.4825

>AT269302 WP_232500621.1 NZ_CP116886:870440-870724 [Thermococcus kodakarensis]
VIPVVSIRLKVGPKGQIVIPKVFREAYGIKEGGEVIVEPREDALVIRRVPDTEELLKKLREYHKKRKGAKPAKLGELKGV
SLEDEFDEVWGIEE

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q5JIF0

Antitoxin

Source ID Structure

References