Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 382103..382731 Replicon chromosome
Accession NZ_CP116886
Organism Thermococcus kodakarensis strain TS901

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag POG21_RS02340 Protein ID WP_011249411.1
Coordinates 382103..382516 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5JGA7
Locus tag POG21_RS02345 Protein ID WP_011249412.1
Coordinates 382504..382731 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
POG21_RS02315 (POG21_02315) 377437..378636 - 1200 WP_011249406.1 type I-A CRISPR-associated protein Cas8a2/Csx9 -
POG21_RS02320 (POG21_02320) 378626..379348 - 723 WP_232500599.1 type I-A CRISPR-associated protein Cas5a -
POG21_RS02325 (POG21_02325) 379371..380570 - 1200 WP_048053661.1 DevR family CRISPR-associated autoregulator -
POG21_RS02330 (POG21_02330) 380570..380926 - 357 WP_048053662.1 type I-A CRISPR-associated protein Csa5 -
POG21_RS02335 (POG21_02335) 381110..382090 - 981 WP_011249410.1 type I-B CRISPR-associated endonuclease Cas1b -
POG21_RS02340 (POG21_02340) 382103..382516 - 414 WP_011249411.1 PIN domain-containing protein Toxin
POG21_RS02345 (POG21_02345) 382504..382731 - 228 WP_011249412.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
POG21_RS02350 (POG21_02350) 382788..383300 - 513 WP_011249413.1 CRISPR-associated protein Cas4 -
POG21_RS02355 (POG21_02355) 383290..384399 - 1110 WP_011249414.1 ATP-binding protein -
POG21_RS02360 (POG21_02360) 384460..386682 - 2223 WP_011249415.1 CRISPR-associated helicase/endonuclease Cas3 -
POG21_RS02365 (POG21_02365) 386679..387311 - 633 WP_011249416.1 type I-B CRISPR-associated protein Cas5b -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-126)

Antitoxin

SpoVT-AbrB domain

(4-43)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16195.78 Da        Isoelectric Point: 9.5452

>T269301 WP_011249411.1 NZ_CP116886:c382516-382103 [Thermococcus kodakarensis]
MHAVIDTNVLLYDTFEDLPFHHKARRLLDSLDRWYVPPIVLQEYVWFFRRKNLPVKLARSMLSEYLDDPRFNRLNDNGES
IVYALELIEKNSLSLSRFNDAIILYHALQRSYPLATFDKKFRKLAVKNGVEVLPAKV

Download         Length: 414 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8749.31 Da        Isoelectric Point: 5.2824

>AT269301 WP_011249412.1 NZ_CP116886:c382731-382504 [Thermococcus kodakarensis]
MPVTKVTRNYQITLPAEIRKALGIEEGELLEVELEGEKIVVKRLKRRRKTLKLGERLTPEEIEKVIEEGMEECMQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB Q5JGA7

References