Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1293723..1294639 Replicon chromosome
Accession NZ_CP116870
Organism Bacillus subtilis subsp. subtilis strain Master_strain

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag PPM45_RS06750 Protein ID WP_003244695.1
Coordinates 1293893..1294639 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag PPM45_RS06745 Protein ID WP_003232646.1
Coordinates 1293723..1293893 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PPM45_RS06720 1289372..1290814 + 1443 WP_003245710.1 tagaturonate reductase -
PPM45_RS06725 1290811..1292304 + 1494 WP_003245409.1 UxaA family hydrolase -
PPM45_RS06730 1292343..1293107 - 765 WP_064635417.1 sulfite exporter TauE/SafE family protein -
PPM45_RS06735 1293143..1293463 + 321 Protein_1262 peptidoglycan-binding domain-containing protein -
PPM45_RS06740 1293500..1293637 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
PPM45_RS06745 1293723..1293893 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
PPM45_RS06750 1293893..1294639 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
PPM45_RS06755 1294749..1295750 - 1002 WP_003232642.1 inorganic phosphate transporter -
PPM45_RS06760 1295763..1296380 - 618 WP_003218470.1 DUF47 domain-containing protein -
PPM45_RS06765 1296656..1297972 - 1317 WP_003244819.1 serine/threonine exchanger -
PPM45_RS06770 1298361..1299311 + 951 WP_003245086.1 ring-cleaving dioxygenase -
PPM45_RS06775 1299412..1299558 + 147 WP_003244977.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T269297 WP_003244695.1 NZ_CP116870:c1294639-1293893 [Bacillus subtilis subsp. subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT269297 WP_003232646.1 NZ_CP116870:c1293893-1293723 [Bacillus subtilis subsp. subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References