269293

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1165572..1166488 Replicon chromosome
Accession NZ_CP116869
Organism Bacillus subtilis subsp. subtilis strain MGP001

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag PPM34_RS06105 Protein ID WP_003244695.1
Coordinates 1165742..1166488 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag PPM34_RS06100 Protein ID WP_003232646.1
Coordinates 1165572..1165742 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PPM34_RS06075 1161221..1162663 + 1443 WP_003245710.1 tagaturonate reductase -
PPM34_RS06080 1162660..1164153 + 1494 WP_003245409.1 UxaA family hydrolase -
PPM34_RS06085 1164192..1164956 - 765 WP_064635417.1 sulfite exporter TauE/SafE family protein -
PPM34_RS06090 1164992..1165312 + 321 Protein_1133 peptidoglycan-binding domain-containing protein -
PPM34_RS06095 1165349..1165486 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
PPM34_RS06100 1165572..1165742 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
PPM34_RS06105 1165742..1166488 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
PPM34_RS06110 1166598..1167599 - 1002 WP_003232642.1 inorganic phosphate transporter -
PPM34_RS06115 1167612..1168229 - 618 WP_003218470.1 DUF47 domain-containing protein -
PPM34_RS06120 1168505..1169821 - 1317 WP_003244819.1 serine/threonine exchanger -
PPM34_RS06125 1170210..1171160 + 951 WP_003245086.1 ring-cleaving dioxygenase -
PPM34_RS06130 1171261..1171407 + 147 WP_003244977.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T269293 WP_003244695.1 NZ_CP116869:c1166488-1165742 [Bacillus subtilis subsp. subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT269293 WP_003232646.1 NZ_CP116869:c1165742-1165572 [Bacillus subtilis subsp. subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
AlphaFold DB G4EXD8

References