Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1088460..1089376 Replicon chromosome
Accession NZ_CP116865
Organism Bacillus subtilis subsp. subtilis strain MGP016

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag PPM43_RS05705 Protein ID WP_003244695.1
Coordinates 1088630..1089376 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag PPM43_RS05700 Protein ID WP_003232646.1
Coordinates 1088460..1088630 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PPM43_RS05675 1084109..1085551 + 1443 WP_003245710.1 tagaturonate reductase -
PPM43_RS05680 1085548..1087041 + 1494 WP_003245409.1 UxaA family hydrolase -
PPM43_RS05685 1087080..1087844 - 765 WP_064635417.1 sulfite exporter TauE/SafE family protein -
PPM43_RS05690 1087880..1088200 + 321 Protein_1053 peptidoglycan-binding domain-containing protein -
PPM43_RS05695 1088237..1088374 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
PPM43_RS05700 1088460..1088630 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
PPM43_RS05705 1088630..1089376 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
PPM43_RS05710 1089486..1090487 - 1002 WP_003232642.1 inorganic phosphate transporter -
PPM43_RS05715 1090500..1091117 - 618 WP_003218470.1 DUF47 domain-containing protein -
PPM43_RS05720 1091393..1092709 - 1317 WP_003244819.1 serine/threonine exchanger -
PPM43_RS05725 1093098..1094048 + 951 WP_003245086.1 ring-cleaving dioxygenase -
PPM43_RS05730 1094149..1094295 + 147 WP_003244977.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T269277 WP_003244695.1 NZ_CP116865:c1089376-1088630 [Bacillus subtilis subsp. subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT269277 WP_003232646.1 NZ_CP116865:c1088630-1088460 [Bacillus subtilis subsp. subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References