Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1085755..1086671 Replicon chromosome
Accession NZ_CP116864
Organism Bacillus subtilis subsp. subtilis strain MGP022

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag PPM28_RS05675 Protein ID WP_003244695.1
Coordinates 1085925..1086671 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag PPM28_RS05670 Protein ID WP_003232646.1
Coordinates 1085755..1085925 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PPM28_RS05645 1081404..1082846 + 1443 WP_003245710.1 tagaturonate reductase -
PPM28_RS05650 1082843..1084336 + 1494 WP_003245409.1 UxaA family hydrolase -
PPM28_RS05655 1084375..1085139 - 765 WP_064635417.1 sulfite exporter TauE/SafE family protein -
PPM28_RS05660 1085175..1085495 + 321 Protein_1047 peptidoglycan-binding domain-containing protein -
PPM28_RS05665 1085532..1085669 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
PPM28_RS05670 1085755..1085925 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
PPM28_RS05675 1085925..1086671 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
PPM28_RS05680 1086781..1087782 - 1002 WP_003232642.1 inorganic phosphate transporter -
PPM28_RS05685 1087795..1088412 - 618 WP_003218470.1 DUF47 domain-containing protein -
PPM28_RS05690 1088688..1090004 - 1317 WP_003244819.1 serine/threonine exchanger -
PPM28_RS05695 1090393..1091343 + 951 WP_003245086.1 ring-cleaving dioxygenase -
PPM28_RS05700 1091444..1091590 + 147 WP_003244977.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T269273 WP_003244695.1 NZ_CP116864:c1086671-1085925 [Bacillus subtilis subsp. subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT269273 WP_003232646.1 NZ_CP116864:c1085925-1085755 [Bacillus subtilis subsp. subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References