Detailed information of TA system TA026927

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2924972..2925686
• Replicon: chromosome
• Accession: NC_017524
• Organism: Mycobacterium tuberculosis CTRI-2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TQK0
• Locus tag: MTCTRI2_RS13735
• Protein ID: WP_003413460.1
• Coordinates: 2925246..2925686 (+)
• Length: 147 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MTCTRI2_RS13730
• Protein ID: WP_014585546.1
• Coordinates: 2924972..2925259 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTCTRI2_RS13695	2920394..2920639	+	246	WP_003413429.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
MTCTRI2_RS13700	2920636..2921040	+	405	WP_003899389.1	type II toxin-antitoxin system VapC family toxin	-
MTCTRI2_RS13705	2921257..2921877	+	621	WP_003413441.1	DUF4178 domain-containing protein	-
MTCTRI2_RS13710	2921888..2922382	+	495	WP_003413444.1	DUF2617 family protein	-
MTCTRI2_RS13715	2922379..2922810	+	432	WP_003899390.1	DUF4247 domain-containing protein	-
MTCTRI2_RS13720	2922835..2923293	+	459	WP_003413451.1	DUF350 domain-containing protein	-
MTCTRI2_RS13725	2923290..2924861	+	1572	WP_003899392.1	polyamine aminopropyltransferase	-
MTCTRI2_RS13730	2924972..2925259	+	288	WP_014585546.1	antitoxin	Antitoxin
MTCTRI2_RS13735	2925246..2925686	+	441	WP_003413460.1	type II toxin-antitoxin system VapC family toxin	Toxin
MTCTRI2_RS13740	2925707..2926462	-	756	WP_003413464.1	YebC/PmpR family DNA-binding transcriptional regulator	-
MTCTRI2_RS13745	2926595..2927191	-	597	WP_003413465.1	pyridoxal 5'-phosphate synthase glutaminase subunit PdxT	-
MTCTRI2_RS13750	2927199..2928044	-	846	WP_003413466.1	acyl-CoA thioesterase II	-
MTCTRI2_RS13755	2928073..2928972	-	900	WP_003413468.1	pyridoxal 5'-phosphate synthase lyase subunit PdxS	-
MTCTRI2_RS13760	2929100..2929774	+	675	WP_003413471.1	pyridoxamine 5'-phosphate oxidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-146)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 147 a.a.
• Molecular weight: 16026.38 Da
• Isoelectric Point: 6.8599

>T26927 WP_003413460.1 NC_017524:2925246-2925686 [Mycobacterium tuberculosis CTRI-2]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Nucleotide

• Length: 441 bp

>T26927 NC_017524:2925246-2925686 [Mycobacterium tuberculosis CTRI-2]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10514.08 Da
• Isoelectric Point: 7.2797

>AT26927 WP_014585546.1 NC_017524:2924972-2925259 [Mycobacterium tuberculosis CTRI-2]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLFQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Nucleotide

• Length: 288 bp

>AT26927 NC_017524:2924972-2925259 [Mycobacterium tuberculosis CTRI-2]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTTCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Structures

Toxin

• AlphaFold DB: G0TQK0