269265

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1040363..1041279 Replicon chromosome
Accession NZ_CP116862
Organism Bacillus subtilis subsp. subtilis strain MGP029

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag PPM42_RS05425 Protein ID WP_003244695.1
Coordinates 1040533..1041279 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag PPM42_RS05420 Protein ID WP_003232646.1
Coordinates 1040363..1040533 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PPM42_RS05395 1036012..1037454 + 1443 WP_003245710.1 tagaturonate reductase -
PPM42_RS05400 1037451..1038944 + 1494 WP_003245409.1 UxaA family hydrolase -
PPM42_RS05405 1038983..1039747 - 765 WP_064635417.1 sulfite exporter TauE/SafE family protein -
PPM42_RS05410 1039783..1040103 + 321 Protein_997 peptidoglycan-binding domain-containing protein -
PPM42_RS05415 1040140..1040277 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
PPM42_RS05420 1040363..1040533 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
PPM42_RS05425 1040533..1041279 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
PPM42_RS05430 1041389..1042390 - 1002 WP_003232642.1 inorganic phosphate transporter -
PPM42_RS05435 1042403..1043020 - 618 WP_003218470.1 DUF47 domain-containing protein -
PPM42_RS05440 1043296..1044612 - 1317 WP_003244819.1 serine/threonine exchanger -
PPM42_RS05445 1045001..1045951 + 951 WP_003245086.1 ring-cleaving dioxygenase -
PPM42_RS05450 1046052..1046198 + 147 WP_003244977.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T269265 WP_003244695.1 NZ_CP116862:c1041279-1040533 [Bacillus subtilis subsp. subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT269265 WP_003232646.1 NZ_CP116862:c1040533-1040363 [Bacillus subtilis subsp. subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
AlphaFold DB G4EXD8

References