269261

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1039385..1040301 Replicon chromosome
Accession NZ_CP116861
Organism Bacillus subtilis subsp. subtilis strain MGP033

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag PPM39_RS05400 Protein ID WP_003244695.1
Coordinates 1039555..1040301 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag PPM39_RS05395 Protein ID WP_003232646.1
Coordinates 1039385..1039555 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PPM39_RS05370 1035034..1036476 + 1443 WP_003245710.1 tagaturonate reductase -
PPM39_RS05375 1036473..1037966 + 1494 WP_003245409.1 UxaA family hydrolase -
PPM39_RS05380 1038005..1038769 - 765 WP_064635417.1 sulfite exporter TauE/SafE family protein -
PPM39_RS05385 1038805..1039125 + 321 Protein_992 peptidoglycan-binding domain-containing protein -
PPM39_RS05390 1039162..1039299 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
PPM39_RS05395 1039385..1039555 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
PPM39_RS05400 1039555..1040301 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
PPM39_RS05405 1040411..1041412 - 1002 WP_003232642.1 inorganic phosphate transporter -
PPM39_RS05410 1041425..1042042 - 618 WP_003218470.1 DUF47 domain-containing protein -
PPM39_RS05415 1042318..1043634 - 1317 WP_003244819.1 serine/threonine exchanger -
PPM39_RS05420 1044023..1044973 + 951 WP_003245086.1 ring-cleaving dioxygenase -
PPM39_RS05425 1045074..1045220 + 147 WP_003244977.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T269261 WP_003244695.1 NZ_CP116861:c1040301-1039555 [Bacillus subtilis subsp. subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT269261 WP_003232646.1 NZ_CP116861:c1039555-1039385 [Bacillus subtilis subsp. subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References