Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 1656..2827 Replicon plasmid p32P1CEA3
Accession NZ_CP116815
Organism Ligilactobacillus salivarius strain P1CEA3

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag POF44_RS09940 Protein ID WP_279280969.1
Coordinates 1931..2827 (+) Length 299 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID V5E259
Locus tag POF44_RS09935 Protein ID WP_007124950.1
Coordinates 1656..1928 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
POF44_RS09930 (POF44_09930) 1..1098 + 1098 WP_279280968.1 replication initiator protein A -
POF44_RS09935 (POF44_09935) 1656..1928 + 273 WP_007124950.1 epsilon-antitoxin Antitoxin
POF44_RS09940 (POF44_09940) 1931..2827 + 897 WP_279280969.1 zeta toxin family protein Toxin
POF44_RS09945 (POF44_09945) 2850..3125 - 276 WP_279280970.1 conjugal transfer protein TraD -
POF44_RS09950 (POF44_09950) 3151..3378 - 228 WP_003650129.1 hypothetical protein -
POF44_RS09955 (POF44_09955) 3654..5714 + 2061 WP_279280971.1 MobQ family relaxase -
POF44_RS09960 (POF44_09960) 5689..6403 + 715 Protein_6 DNA topoisomerase -
POF44_RS09965 (POF44_09965) 7027..7278 + 252 WP_032811335.1 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..32196 32196


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(24-213)

Antitoxin

Bacterial epsilon antitoxin

(4-90)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 34448.14 Da        Isoelectric Point: 6.8927

>T269259 WP_279280969.1 NZ_CP116815:1931-2827 [Ligilactobacillus salivarius]
MDELANYTDYQFAVKLQIEIEQLTKNKQAQASPKAYLLGGQPGAGKSGLHQLIKAQDPNAITIDNDTFKWLHPKYQQLEQ
KYGKDVVKYVTPFSNRMTESLIDYLSDKKFDLIIEGTLRTVEVPMATVTKLQNRGYEASLYVMAVPRIESYLGTLARYED
QFSLSPRTARATSKEAHDVVVRQLPDNLDFLYKQRLFKEIRLYDRKGNKLYSSLENLDESPKQIITEILNRKLENNTLFN
SIDSVIKKMESNQHTTTPQYLDLVEKTTELKKEISDKVQEQLKEFAEQNPDIKQPENK

Download         Length: 897 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10340.91 Da        Isoelectric Point: 5.5093

>AT269259 WP_007124950.1 NZ_CP116815:1656-1928 [Ligilactobacillus salivarius]
MKLDYQQTYKKEILTEFASSIYAKVVNLVVDQELNIHDESHFLVKLMHQLGDAKLVIMDAHSLGELETIQAYWQAMNNFI
DSLPTKSKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V5E259

References