Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1049766..1050305 Replicon chromosome
Accession NZ_CP116807
Organism Mammaliicoccus lentus strain PVZ.22

Toxin (Protein)


Gene name mazF Uniprot ID A0A178P0V5
Locus tag PN942_RS05355 Protein ID WP_016999692.1
Coordinates 1049766..1050137 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A4Y9KBD3
Locus tag PN942_RS05360 Protein ID WP_016999693.1
Coordinates 1050138..1050305 (-) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PN942_RS05335 (PN942_05330) 1047036..1047806 - 771 WP_016999688.1 RNA polymerase sigma factor SigB -
PN942_RS05340 (PN942_05335) 1047781..1048257 - 477 WP_016999689.1 anti-sigma B factor RsbW -
PN942_RS05345 (PN942_05340) 1048259..1048585 - 327 WP_016999690.1 anti-sigma factor antagonist -
PN942_RS05350 (PN942_05345) 1048658..1049662 - 1005 WP_016999691.1 PP2C family protein-serine/threonine phosphatase -
PN942_RS05355 (PN942_05350) 1049766..1050137 - 372 WP_016999692.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PN942_RS05360 (PN942_05355) 1050138..1050305 - 168 WP_016999693.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
PN942_RS05365 (PN942_05360) 1050392..1051540 - 1149 WP_016999694.1 alanine racemase -
PN942_RS05370 (PN942_05365) 1051588..1051956 - 369 WP_016999695.1 holo-ACP synthase -
PN942_RS05375 (PN942_05370) 1051953..1052453 - 501 WP_016999696.1 PH domain-containing protein -
PN942_RS05380 (PN942_05375) 1052443..1053975 - 1533 WP_016999697.1 PH domain-containing protein -
PN942_RS05385 (PN942_05380) 1053965..1054444 - 480 WP_016999698.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13662.79 Da        Isoelectric Point: 9.8460

>T269253 WP_016999692.1 NZ_CP116807:c1050137-1049766 [Mammaliicoccus lentus]
MRRGDVYLADLSPVTGSEQGGTRPVVIIQNDTGNRYSPTVIVAAITGKINKAKIPTHVEIEAAKYKLDRDSVILLEQIRT
IDKKRLKEKLTYLSDAKMKEVDSAIAISLNLTLQYKFDTLGNT

Download         Length: 372 bp

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6239.71 Da        Isoelectric Point: 4.0121

>AT269253 WP_016999693.1 NZ_CP116807:c1050305-1050138 [Mammaliicoccus lentus]
MTSLTQNRNQSLEQTLKEGYRYMADLNLSLASEAYYSECEACDSNESHLTSQQGE

Download         Length: 168 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A178P0V5

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y9KBD3

References