Detailed information of TA system TA269248

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 6633402..6633907
• Replicon: chromosome
• Accession: NZ_CP116775
• Organism: Pseudomonas sp. 273

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: PKO50_RS30365
• Protein ID: WP_089392789.1
• Coordinates: 6633626..6633907 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: PKO50_RS30360
• Protein ID: WP_089392790.1
• Coordinates: 6633402..6633629 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PKO50_RS30340	6630022..6630423	-	402	WP_275628080.1	GFA family protein	-
PKO50_RS30345	6630435..6631165	-	731	Protein_5994	phytanoyl-CoA dioxygenase family protein	-
PKO50_RS30350	6631162..6632088	-	927	WP_275628081.1	LysR family transcriptional regulator	-
PKO50_RS30355	6632163..6633119	-	957	WP_275628082.1	agmatinase	-
PKO50_RS30360	6633402..6633629	+	228	WP_089392790.1	CopG family ribbon-helix-helix protein	Antitoxin
PKO50_RS30365	6633626..6633907	+	282	WP_089392789.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PKO50_RS30370	6634166..6634897	+	732	WP_275628083.1	RcnB family protein	-
PKO50_RS30375	6634938..6635219	-	282	WP_109934375.1	DUF2218 domain-containing protein	-
PKO50_RS30380	6635317..6636234	+	918	WP_275628084.1	LysR family transcriptional regulator	-
PKO50_RS30385	6636293..6636748	+	456	WP_275628085.1	GNAT family N-acetyltransferase	-
PKO50_RS30390	6636745..6637362	-	618	WP_275628086.1	DUF1826 domain-containing protein	-
PKO50_RS30395	6637362..6638564	-	1203	WP_275628087.1	zinc metallochaperone GTPase ZigA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10269.77 Da
• Isoelectric Point: 6.4614

>T269248 WP_089392789.1 NZ_CP116775:6633626-6633907 [Pseudomonas sp. 273]
MSLQWTHKAAADLDGLYDHYVVLIGPEKALKAVQDMVGQVKALADLSLSSVGRPSEVPGVRELPLERWPYQAAYRVKGRD
VQILRIDSVDNPG

Nucleotide

• Length: 282 bp

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8385.43 Da
• Isoelectric Point: 6.6405

>AT269248 WP_089392790.1 NZ_CP116775:6633402-6633629 [Pseudomonas sp. 273]
MTTVISFRADDALARALDQLARATHRDRPYHLRQALAQYLERQSWHVAAIDEGLADANAGHLLPHAEIEAKWGLA

Nucleotide

• Length: 228 bp