Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 6100092..6100710 Replicon chromosome
Accession NZ_CP116775
Organism Pseudomonas sp. 273

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PKO50_RS27995 Protein ID WP_275627849.1
Coordinates 6100528..6100710 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PKO50_RS27990 Protein ID WP_275627848.1
Coordinates 6100092..6100496 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PKO50_RS27975 6095736..6099469 + 3734 Protein_5523 EAL domain-containing protein -
PKO50_RS27985 6099634..6099924 - 291 WP_089392953.1 helix-turn-helix domain-containing protein -
PKO50_RS27990 6100092..6100496 - 405 WP_275627848.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PKO50_RS27995 6100528..6100710 - 183 WP_275627849.1 type II toxin-antitoxin system HicA family toxin Toxin
PKO50_RS28000 6101169..6101657 + 489 WP_275627850.1 Bro-N domain-containing protein -
PKO50_RS28005 6101916..6102074 - 159 WP_009615518.1 YqaE/Pmp3 family membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6962.13 Da        Isoelectric Point: 12.1410

>T269246 WP_275627849.1 NZ_CP116775:c6100710-6100528 [Pseudomonas sp. 273]
MRSREIMELIRADGWFLVEVKGGHHQFRHFTKKGWVTVPHPRSNLPIGTVNSILRQAGLR

Download         Length: 183 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14604.30 Da        Isoelectric Point: 4.4720

>AT269246 WP_275627848.1 NZ_CP116775:c6100496-6100092 [Pseudomonas sp. 273]
MKFPVVLHKDADSDYGVTIPDVPGCFSAGGTVSQALENVQEALALHFEGLVADDETLPQAQEVDTHMGNPDYAGGVWAVV
DFDVTPYLGKAVRFNATLPENLLQRIDERVKRDHRYASRSGFLATAALRELSSN

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References