Detailed information of TA system TA269240

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): slvAT/RES(toxin)
• Location: 1964972..1965864
• Replicon: chromosome
• Accession: NZ_CP116775
• Organism: Pseudomonas sp. 273

Toxin (Protein)

• Gene name: slvT
• Uniprot ID: -
• Locus tag: PKO50_RS09440
• Protein ID: WP_275629484.1
• Coordinates: 1965340..1965864 (+)
• Length: 175 a.a.

Antitoxin (Protein)

• Gene name: slvA
• Uniprot ID: -
• Locus tag: PKO50_RS09435
• Protein ID: WP_275629483.1
• Coordinates: 1964972..1965343 (+)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PKO50_RS09400	1960127..1960897	-	771	WP_275629478.1	hypothetical protein	-
PKO50_RS09405	1960942..1962252	-	1311	WP_275629479.1	hypothetical protein	-
PKO50_RS09410	1962290..1962679	-	390	WP_275629480.1	type II toxin-antitoxin system VapC family toxin	-
PKO50_RS09415	1962679..1962891	-	213	WP_275629481.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
PKO50_RS09420	1962963..1963897	-	935	Protein_1865	DUF3363 domain-containing protein	-
PKO50_RS09425	1963897..1964217	-	321	Protein_1866	Arm DNA-binding domain-containing protein	-
PKO50_RS09430	1964597..1964794	-	198	WP_275629482.1	hypothetical protein	-
PKO50_RS09435	1964972..1965343	+	372	WP_275629483.1	DUF2384 domain-containing protein	Antitoxin
PKO50_RS09440	1965340..1965864	+	525	WP_275629484.1	RES family NAD+ phosphorylase	Toxin
PKO50_RS09445	1965878..1968739	-	2862	WP_275629485.1	conjugative transfer ATPase	-
PKO50_RS09450	1968739..1969173	-	435	WP_275629486.1	TIGR03751 family conjugal transfer lipoprotein	-
PKO50_RS09455	1969154..1970574	-	1421	Protein_1872	TIGR03752 family integrating conjugative element protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1820837..2194583	373746

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (14-168)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (71-120)

Sequences

Toxin

Protein

• Length: 175 a.a.
• Molecular weight: 19270.64 Da
• Isoelectric Point: 4.5023

>T269240 WP_275629484.1 NZ_CP116775:1965340-1965864 [Pseudomonas sp. 273]
MISKTLGADGDEAFYRVIVPAYAGTPLSGMGAARQGGRFNRPDQEALYLALDESTALAEYKQDNPWLRPGTICTFFINGL
RVADLSAGFDPDRWPPLWADYTVDWRAEWFDKSVEPPTWYMADDVVAAGLDGILFPSQARPGGTNLVIYHSSSRPAAQLR
VYDPDGALQRLINR

Nucleotide

• Length: 525 bp

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 13777.67 Da
• Isoelectric Point: 7.3173

>AT269240 WP_275629483.1 NZ_CP116775:1964972-1965343 [Pseudomonas sp. 273]
MNTVLQEPFVERFREPNTPYLSPSKVGDFFGFRVQELAERAHVHRNTPTARPQAPQLQKYLQDMVRVLAVATEMTGDVHR
AVFLLRNEPLRAFGYKTADTLIQEGRADAVIAYLESFAGGAAG

Nucleotide

• Length: 372 bp