Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
| Location | 2863057..2863766 | Replicon | chromosome |
| Accession | NC_017524 | ||
| Organism | Mycobacterium tuberculosis CTRI-2 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | G0TQ26 |
| Locus tag | MTCTRI2_RS13445 | Protein ID | WP_003413164.1 |
| Coordinates | 2863057..2863470 (+) | Length | 138 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | P95006 |
| Locus tag | MTCTRI2_RS13450 | Protein ID | WP_003413167.1 |
| Coordinates | 2863509..2863766 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MTCTRI2_RS13415 | 2858110..2859315 | - | 1206 | WP_003413027.1 | chorismate synthase | - |
| MTCTRI2_RS13420 | 2859423..2859737 | + | 315 | WP_009937839.1 | hypothetical protein | - |
| MTCTRI2_RS13425 | 2860033..2861244 | + | 1212 | WP_003900845.1 | alpha/beta hydrolase family protein | - |
| MTCTRI2_RS13430 | 2861371..2862030 | + | 660 | WP_014585545.1 | LppA family lipoprotein | - |
| MTCTRI2_RS13435 | 2862027..2862689 | + | 663 | WP_003900848.1 | hypothetical protein | - |
| MTCTRI2_RS13440 | 2862686..2862964 | + | 279 | WP_003901422.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| MTCTRI2_RS13445 | 2863057..2863470 | + | 414 | WP_003413164.1 | PIN domain nuclease | Toxin |
| MTCTRI2_RS13450 | 2863509..2863766 | + | 258 | WP_003413167.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
| MTCTRI2_RS13455 | 2863763..2864140 | + | 378 | WP_003413174.1 | type II toxin-antitoxin system VapC family toxin | - |
| MTCTRI2_RS13460 | 2864156..2864530 | - | 375 | WP_003413177.1 | hypothetical protein | - |
| MTCTRI2_RS13465 | 2864630..2865025 | - | 396 | WP_003413180.1 | type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 | - |
| MTCTRI2_RS13470 | 2865022..2865267 | - | 246 | WP_003413183.1 | type II toxin-antitoxin system antitoxin VapB20 | - |
| MTCTRI2_RS13475 | 2865678..2866097 | - | 420 | WP_003413190.1 | A24 family peptidase | - |
| MTCTRI2_RS13480 | 2866109..2866918 | - | 810 | WP_003413193.1 | shikimate dehydrogenase | - |
| MTCTRI2_RS13485 | 2866915..2868168 | - | 1254 | WP_003413196.1 | endolytic transglycosylase MltG | - |
| MTCTRI2_RS13490 | 2868161..2868673 | - | 513 | WP_003413197.1 | Holliday junction resolvase RuvX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 138 a.a. Molecular weight: 15045.00 Da Isoelectric Point: 5.4673
>T26924 WP_003413164.1 NC_017524:2863057-2863470 [Mycobacterium tuberculosis CTRI-2]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL
Download Length: 414 bp
>T26924 NC_017524:2863057-2863470 [Mycobacterium tuberculosis CTRI-2]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9453.63 Da Isoelectric Point: 10.6555
>AT26924 WP_003413167.1 NC_017524:2863509-2863766 [Mycobacterium tuberculosis CTRI-2]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA
Download Length: 258 bp
>AT26924 NC_017524:2863509-2863766 [Mycobacterium tuberculosis CTRI-2]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TQ26 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829C9W5 |