Detailed information of TA system TA026923

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2849171..2849811
• Replicon: chromosome
• Accession: NC_017524
• Organism: Mycobacterium tuberculosis CTRI-2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TQ08
• Locus tag: MTCTRI2_RS13360
• Protein ID: WP_003412970.1
• Coordinates: 2849171..2849590 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TQ09
• Locus tag: MTCTRI2_RS13365
• Protein ID: WP_003412975.1
• Coordinates: 2849587..2849811 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTCTRI2_RS13335	2844756..2845478	-	723	WP_003412957.1	DUF1906 domain-containing protein	-
MTCTRI2_RS13340	2845995..2846222	+	228	WP_003412960.1	type II toxin-antitoxin system VapB family antitoxin	-
MTCTRI2_RS13345	2846219..2846620	+	402	WP_003412963.1	PIN domain-containing protein	-
MTCTRI2_RS13350	2846655..2847575	-	921	WP_003412965.1	restriction endonuclease	-
MTCTRI2_RS22515	2847916..2848161	-	246	WP_071854223.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
MTCTRI2_RS13355	2848220..2849170	+	951	WP_003911916.1	Lsr2 family protein	-
MTCTRI2_RS13360	2849171..2849590	-	420	WP_003412970.1	type II toxin-antitoxin system VapC family toxin	Toxin
MTCTRI2_RS13365	2849587..2849811	-	225	WP_003412975.1	antitoxin VapB39	Antitoxin
MTCTRI2_RS13370	2849842..2852685	-	2844	WP_003899363.1	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
MTCTRI2_RS13375	2852756..2853157	-	402	WP_003412981.1	hypothetical protein	-
MTCTRI2_RS13380	2853157..2853627	-	471	WP_003899364.1	transcription antitermination factor NusB	-
MTCTRI2_RS13385	2853630..2854193	-	564	WP_003412989.1	elongation factor P	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14732.70 Da
• Isoelectric Point: 6.7519

>T26923 WP_003412970.1 NC_017524:c2849590-2849171 [Mycobacterium tuberculosis CTRI-2]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Nucleotide

• Length: 420 bp

>T26923 NC_017524:c2849590-2849171 [Mycobacterium tuberculosis CTRI-2]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 7993.94 Da
• Isoelectric Point: 4.0057

>AT26923 WP_003412975.1 NC_017524:c2849811-2849587 [Mycobacterium tuberculosis CTRI-2]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Nucleotide

• Length: 225 bp

>AT26923 NC_017524:c2849811-2849587 [Mycobacterium tuberculosis CTRI-2]
ATGCGCACCACGTTGCAGATTGATGATGATGTTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA

Structures

Toxin

• AlphaFold DB: G0TQ08

Antitoxin

• AlphaFold DB: G0TQ09