Detailed information of TA system TA269228

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2372308..2373965
• Replicon: chromosome
• Accession: NZ_CP116770
• Organism: Brevundimonas sp. 2003-09-23

Toxin (Protein)

• Gene name: HipA3
• Uniprot ID: -
• Locus tag: PIB44_RS11735
• Protein ID: WP_278069517.1
• Coordinates: 2372649..2373965 (+)
• Length: 439 a.a.

Antitoxin (Protein)

• Gene name: HipB3
• Uniprot ID: -
• Locus tag: PIB44_RS11730
• Protein ID: WP_278069516.1
• Coordinates: 2372308..2372652 (+)
• Length: 115 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PIB44_RS11710	2367522..2368649	+	1128	WP_278069512.1	type IV secretion system protein VirB10	-
PIB44_RS11715	2368649..2369659	+	1011	WP_278069513.1	P-type DNA transfer ATPase VirB11	-
PIB44_RS11720	2369625..2371496	+	1872	WP_278069514.1	type IV secretory system conjugative DNA transfer family protein	-
PIB44_RS11725	2371496..2372149	+	654	WP_278069515.1	hypothetical protein	-
PIB44_RS11730	2372308..2372652	+	345	WP_278069516.1	helix-turn-helix transcriptional regulator	Antitoxin
PIB44_RS11735	2372649..2373965	+	1317	WP_278069517.1	type II toxin-antitoxin system HipA family toxin	Toxin
PIB44_RS11740	2373973..2375004	-	1032	WP_278069518.1	hypothetical protein	-
PIB44_RS11745	2375001..2375522	-	522	WP_278069519.1	plasmid mobilization relaxosome protein MobC	-
PIB44_RS11750	2375759..2376634	-	876	WP_278069520.1	zincin-like metallopeptidase domain-containing protein	-
PIB44_RS11755	2376705..2376998	-	294	WP_278069521.1	DUF736 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (169-406)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-67)

Sequences

Toxin

Protein

• Length: 439 a.a.
• Molecular weight: 48519.81 Da
• Isoelectric Point: 5.4966

>T269228 WP_278069517.1 NZ_CP116770:2372649-2373965 [Brevundimonas sp. 2003-09-23]
MTDAVVRLWGTDIGAVSWVEARGHAVFQYMPDFLGSGVELAPLVMPLNAAPYAFPELPRDAFKGLPGLLADSLPDKYGNA
LIDAWLAREGRDAASFNPVERLCYIGTRGMGALEFHPTILKTERRSRPIQIDALVDLANQVLDARADLHGVLSGEDDRDT
LEEILRVGTSAGGACAKAVLAWNEATGEFRSGQLPADAGFTYWLIKFDGVSNNRDKELADPQGFGLIEYAFSRMAADAGV
DMSECRLHQEGGRSHFMTRRFDRRATGDKLHMQSLAAIRHFDFNAAGAYAYEQAVETIRRLGLPAVDIEQQFRRAVFNIL
IRNQDDHVKNIAFLMDRTGAWRLSPAYDVAYAYNPSGPWTRQHQMSLNGKRDDFDLEDLVAFGGYCGFSRRRALALVEEV
SAPVSAWRAYADDAGVYEADAVRIQRALRLELKAARPA

Nucleotide

• Length: 1317 bp

Antitoxin

Protein

• Length: 115 a.a.
• Molecular weight: 12444.19 Da
• Isoelectric Point: 11.1229

>AT269228 WP_278069516.1 NZ_CP116770:2372308-2372652 [Brevundimonas sp. 2003-09-23]
MPIAEAEIDRQAERLGRGLAAERLSRNLTQAQLATEAGLSLSTLRRLEDGKNISLDNLIRVMDALQIAGRLDALTPALDI
RPVERVRPAGRERKRAAPAASPPPASRWAWGDQS

Nucleotide

• Length: 345 bp