Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 1717265..1717848 Replicon chromosome
Accession NZ_CP116766
Organism Neisseria sp. ZJ106

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag PJU73_RS07925 Protein ID WP_237090730.1
Coordinates 1717265..1717606 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag PJU73_RS07930 Protein ID WP_237090729.1
Coordinates 1717606..1717848 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PJU73_RS07905 (PJU73_07905) 1712774..1713640 - 867 WP_237090734.1 ribosome small subunit-dependent GTPase A -
PJU73_RS07910 (PJU73_07910) 1713779..1714153 + 375 WP_237090733.1 hypothetical protein -
PJU73_RS07915 (PJU73_07915) 1714300..1715670 - 1371 WP_237090732.1 adenylosuccinate lyase -
PJU73_RS07920 (PJU73_07920) 1716028..1717131 - 1104 WP_237090731.1 peptide chain release factor 2 -
PJU73_RS07925 (PJU73_07925) 1717265..1717606 - 342 WP_237090730.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PJU73_RS07930 (PJU73_07930) 1717606..1717848 - 243 WP_237090729.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
PJU73_RS07935 (PJU73_07935) 1718097..1719878 + 1782 WP_237090728.1 cation:proton antiporter -
PJU73_RS07940 (PJU73_07940) 1720149..1721369 + 1221 WP_237090727.1 serine/threonine transporter SstT -
PJU73_RS07945 (PJU73_07945) 1721486..1721920 - 435 WP_237090726.1 Lrp/AsnC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-110)

Antitoxin

SpoVT-AbrB domain

(4-47)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12515.60 Da        Isoelectric Point: 8.5222

>T269227 WP_237090730.1 NZ_CP116766:c1717606-1717265 [Neisseria sp. ZJ106]
MYIPDKGDIIHLQFDPASGREMKGNHFALVLSSKAFNQKIGLVFACPISQGKADTARGMLSTLLGAGTVLQGNIHCHQLK
SLDWKERRAVLKEKVPDYVLQDVLSRIEAILEL

Download         Length: 342 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8894.22 Da        Isoelectric Point: 6.3439

>AT269227 WP_237090729.1 NZ_CP116766:c1717848-1717606 [Neisseria sp. ZJ106]
MKLQKWGNSAAVRFPKEIISQLGLKIGDELETQAQGDTIVIRAAKRRRYTLAQLLAETPETAPRVAGWEEMAEVGKEVAE

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References