Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 25730..26322 Replicon chromosome
Accession NZ_CP116766
Organism Neisseria sp. ZJ106

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PJU73_RS00125 Protein ID WP_237090307.1
Coordinates 26065..26322 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PJU73_RS00120 Protein ID WP_237090308.1
Coordinates 25730..26068 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PJU73_RS00100 (PJU73_00100) 21181..21684 + 504 WP_237090312.1 GNAT family N-acetyltransferase -
PJU73_RS00105 (PJU73_00105) 21953..23197 - 1245 WP_237090311.1 N-acetylmuramoyl-L-alanine amidase -
PJU73_RS00110 (PJU73_00110) 23185..23655 - 471 WP_237090310.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
PJU73_RS00115 (PJU73_00115) 23834..25018 - 1185 WP_237090309.1 5-demethoxyubiquinol-8 5-hydroxylase UbiM -
PJU73_RS00120 (PJU73_00120) 25730..26068 - 339 WP_237090308.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PJU73_RS00125 (PJU73_00125) 26065..26322 - 258 WP_237090307.1 type II toxin-antitoxin system HicA family toxin Toxin
PJU73_RS00130 (PJU73_00130) 26584..26955 - 372 WP_237090306.1 hypothetical protein -
PJU73_RS00135 (PJU73_00135) 27342..29315 - 1974 WP_237090305.1 DUF927 domain-containing protein -
PJU73_RS00140 (PJU73_00140) 29318..30547 - 1230 WP_237090304.1 toprim domain-containing protein -
PJU73_RS00145 (PJU73_00145) 30553..30714 - 162 WP_237090303.1 hypothetical protein -
PJU73_RS00150 (PJU73_00150) 30711..30953 - 243 WP_237090302.1 hypothetical protein -
PJU73_RS00155 (PJU73_00155) 30950..31312 - 363 WP_237090301.1 S24 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9444.96 Da        Isoelectric Point: 10.5650

>T269226 WP_237090307.1 NZ_CP116766:c26322-26065 [Neisseria sp. ZJ106]
MKKKHQKTLALIFKRPVSGSIKWADIEALFAELGAEIQEREGSRIAVILFGQVQVFHRPHPSPDTDKGAVAAVRKWLEAN
GVTPQ

Download         Length: 258 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12208.66 Da        Isoelectric Point: 4.7583

>AT269226 WP_237090308.1 NZ_CP116766:c26068-25730 [Neisseria sp. ZJ106]
MNNLMNINGHQAVIQYDPETEMLRGEFIGLNGGADFYADNVADLQKEGLISLQTFLDVCKEQGIEPYKHYSGRFNVRVSP
QVHAAAAAAAAASNISLNEWVGRTLDRAAQIG

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References