269224

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09907-MazE
Location 4713..5314 Replicon plasmid pMWLp-12E
Accession NZ_CP116754
Organism Lactiplantibacillus plantarum strain MWLp-12

Toxin (Protein)


Gene name pemK Uniprot ID Q684P1
Locus tag MWLp12_RS16015 Protein ID WP_001748110.1
Coordinates 4970..5314 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag MWLp12_RS16010 Protein ID WP_272524910.1
Coordinates 4713..4976 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MWLp12_RS15990 (MWLp12_pE0001) 93..617 + 525 WP_003646143.1 hypothetical protein -
MWLp12_RS15995 (MWLp12_pE0002) 1603..1899 + 297 WP_146708724.1 hypothetical protein -
MWLp12_RS16005 (MWLp12_pE0005) 4040..4627 - 588 WP_025016518.1 site-specific integrase -
MWLp12_RS16010 (MWLp12_pE0006) 4713..4976 + 264 WP_272524910.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MWLp12_RS16015 (MWLp12_pE0007) 4970..5314 + 345 WP_001748110.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MWLp12_RS16020 (MWLp12_pE0008) 5636..6565 + 930 WP_272524911.1 IS30-like element ISLpl1 family transposase -
MWLp12_RS16025 (MWLp12_pE0009) 6665..7033 + 369 WP_272524912.1 hypothetical protein -
MWLp12_RS16030 (MWLp12_pE0010) 7156..7356 + 201 WP_003643340.1 cold-shock protein -
MWLp12_RS16035 (MWLp12_pE0011) 7443..7685 + 243 WP_003643341.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..8184 8184
- flank IS/Tn - - 5636..6565 929


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-104)

Antitoxin

Antitoxin PemI-like

(8-85)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13041.89 Da        Isoelectric Point: 6.4782

>T269224 WP_001748110.1 NZ_CP116754:4970-5314 [Lactiplantibacillus plantarum]
MVSQGDIFYVNFNPSRGHEQMNKRPAIALSNDLVCQTSNMTIVAPISSTKRNFPMYHRLTSSQTVYGKVLLDQTIALDLR
ARHVTDETIVDHVSREELEEIITLYKLLFSIDDK

Download         Length: 345 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10125.47 Da        Isoelectric Point: 6.4708

>AT269224 WP_272524910.1 NZ_CP116754:4713-4976 [Lactiplantibacillus plantarum]
MEPIKEQTRLAKWGNSKAARIPSQIIKQLKLDDNQDMTITIENGSIVLTPIKKNPTNIHELFKDWKDDGKRDHELDWGKS
EGNELQW

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R2K1X3

Antitoxin

Source ID Structure

References