Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2400684..2401213 Replicon chromosome
Accession NC_017524
Organism Mycobacterium tuberculosis CTRI-2

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag MTCTRI2_RS11260 Protein ID WP_003411124.1
Coordinates 2400684..2401001 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag MTCTRI2_RS11265 Protein ID WP_003411127.1
Coordinates 2400998..2401213 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTCTRI2_RS11230 2395879..2396955 + 1077 WP_003411110.1 hypothetical protein -
MTCTRI2_RS11235 2396952..2397233 + 282 WP_003411112.1 hypothetical protein -
MTCTRI2_RS11240 2397269..2398342 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
MTCTRI2_RS11245 2398347..2398877 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
MTCTRI2_RS11250 2398925..2400271 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
MTCTRI2_RS11260 2400684..2401001 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MTCTRI2_RS11265 2400998..2401213 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
MTCTRI2_RS11270 2401468..2402526 + 1059 WP_003411129.1 hypothetical protein -
MTCTRI2_RS11275 2402656..2403012 - 357 WP_003411130.1 hypothetical protein -
MTCTRI2_RS11280 2403107..2403889 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
MTCTRI2_RS11285 2404157..2404447 - 291 WP_003900476.1 YggT family protein -
MTCTRI2_RS11290 2404609..2405265 - 657 WP_003411133.1 cell division protein SepF -
MTCTRI2_RS11295 2405331..2406107 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T26921 WP_003411124.1 NC_017524:c2401001-2400684 [Mycobacterium tuberculosis CTRI-2]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T26921 NC_017524:c2401001-2400684 [Mycobacterium tuberculosis CTRI-2]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT26921 WP_003411127.1 NC_017524:c2401213-2400998 [Mycobacterium tuberculosis CTRI-2]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT26921 NC_017524:c2401213-2400998 [Mycobacterium tuberculosis CTRI-2]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References