269209

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 5714940..5715526 Replicon chromosome
Accession NZ_CP116725
Organism Pseudomonas aeruginosa strain 2881

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag PMJ88_RS26875 Protein ID WP_003120987.1
Coordinates 5715227..5715526 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag PMJ88_RS26870 Protein ID WP_003448662.1
Coordinates 5714940..5715230 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ88_RS26845 (PMJ88_26845) 5710091..5710300 + 210 WP_003105733.1 cold-shock protein -
PMJ88_RS26850 (PMJ88_26850) 5710522..5712411 + 1890 WP_016851610.1 hypothetical protein -
PMJ88_RS26855 (PMJ88_26855) 5712408..5714384 + 1977 WP_016851611.1 DEAD/DEAH box helicase -
PMJ88_RS26860 (PMJ88_26860) 5714394..5714528 + 135 WP_255253641.1 hypothetical protein -
PMJ88_RS26865 (PMJ88_26865) 5714525..5714869 + 345 WP_016851612.1 hypothetical protein -
PMJ88_RS26870 (PMJ88_26870) 5714940..5715230 - 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
PMJ88_RS26875 (PMJ88_26875) 5715227..5715526 - 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PMJ88_RS26880 (PMJ88_26880) 5715728..5716852 + 1125 WP_012076859.1 TcpQ domain-containing protein -
PMJ88_RS26885 (PMJ88_26885) 5716852..5718561 + 1710 WP_012076860.1 PilN family type IVB pilus formation outer membrane protein -
PMJ88_RS26890 (PMJ88_26890) 5718565..5719890 + 1326 WP_003099758.1 type 4b pilus protein PilO2 -
PMJ88_RS26895 (PMJ88_26895) 5719880..5720413 + 534 WP_003120993.1 type IV pilus biogenesis protein PilP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5685703..5772001 86298


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T269209 WP_003120987.1 NZ_CP116725:c5715526-5715227 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT269209 WP_003448662.1 NZ_CP116725:c5715230-5714940 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References