Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4945701..4946959 Replicon chromosome
Accession NZ_CP116725
Organism Pseudomonas aeruginosa strain 2881

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag PMJ88_RS23185 Protein ID WP_003086331.1
Coordinates 4945701..4946456 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PMJ88_RS23190 Protein ID WP_003086329.1
Coordinates 4946591..4946959 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ88_RS23175 (PMJ88_23175) 4940872..4943415 + 2544 WP_033955245.1 acyl-homoserine-lactone acylase QuiP -
PMJ88_RS23180 (PMJ88_23180) 4943571..4944932 - 1362 WP_003120632.1 DNA recombination protein RmuC -
PMJ88_RS23185 (PMJ88_23185) 4945701..4946456 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
PMJ88_RS23190 (PMJ88_23190) 4946591..4946959 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PMJ88_RS23195 (PMJ88_23195) 4947032..4948318 - 1287 WP_003086327.1 FAD-binding oxidoreductase -
PMJ88_RS23200 (PMJ88_23200) 4948374..4949963 - 1590 WP_023464367.1 aldehyde dehydrogenase family protein -
PMJ88_RS23205 (PMJ88_23205) 4950042..4950518 + 477 WP_004353334.1 elongation factor GreAB -
PMJ88_RS23210 (PMJ88_23210) 4950521..4950796 - 276 WP_023088486.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T269207 WP_003086331.1 NZ_CP116725:c4946456-4945701 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT269207 WP_003086329.1 NZ_CP116725:c4946959-4946591 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References