Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3902106..3903327 Replicon chromosome
Accession NZ_CP116725
Organism Pseudomonas aeruginosa strain 2881

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag PMJ88_RS18205 Protein ID WP_003110488.1
Coordinates 3902749..3903327 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PMJ88_RS18200 Protein ID WP_003088112.1
Coordinates 3902106..3902660 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ88_RS18175 (PMJ88_18175) 3897674..3898225 + 552 WP_003450159.1 XRE family transcriptional regulator -
PMJ88_RS18180 (PMJ88_18180) 3898222..3898620 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
PMJ88_RS18185 (PMJ88_18185) 3898633..3898956 - 324 WP_015648646.1 multidrug efflux SMR transporter -
PMJ88_RS18190 (PMJ88_18190) 3899287..3899748 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
PMJ88_RS18195 (PMJ88_18195) 3899753..3901948 + 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PMJ88_RS18200 (PMJ88_18200) 3902106..3902660 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
PMJ88_RS18205 (PMJ88_18205) 3902749..3903327 + 579 WP_003110488.1 HD domain-containing protein Toxin
PMJ88_RS18210 (PMJ88_18210) 3903436..3904623 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
PMJ88_RS18215 (PMJ88_18215) 3904613..3906784 - 2172 WP_025297367.1 type I secretion system permease/ATPase -
PMJ88_RS18220 (PMJ88_18220) 3906774..3908051 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T269206 WP_003110488.1 NZ_CP116725:3902749-3903327 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT269206 WP_003088112.1 NZ_CP116725:3902106-3902660 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References