269205

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2929255..2930297 Replicon chromosome
Accession NZ_CP116725
Organism Pseudomonas aeruginosa strain 2881

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag PMJ88_RS14025 Protein ID WP_003153636.1
Coordinates 2929722..2930297 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag PMJ88_RS14020 Protein ID WP_003050245.1
Coordinates 2929255..2929725 (+) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ88_RS13985 (PMJ88_13985) 2924647..2926065 - 1419 WP_006226029.1 TIGR03752 family integrating conjugative element protein -
PMJ88_RS13990 (PMJ88_13990) 2926055..2926966 - 912 WP_006226028.1 TIGR03749 family integrating conjugative element protein -
PMJ88_RS13995 (PMJ88_13995) 2926963..2927655 - 693 WP_003090182.1 TIGR03746 family integrating conjugative element protein -
PMJ88_RS14000 (PMJ88_14000) 2927652..2928050 - 399 WP_003050133.1 TIGR03750 family conjugal transfer protein -
PMJ88_RS14005 (PMJ88_14005) 2928062..2928421 - 360 WP_003090173.1 TIGR03745 family integrating conjugative element membrane protein -
PMJ88_RS14010 (PMJ88_14010) 2928438..2928671 - 234 WP_023101201.1 TIGR03758 family integrating conjugative element protein -
PMJ88_RS14015 (PMJ88_14015) 2928668..2929051 - 384 WP_003090167.1 RAQPRD family integrative conjugative element protein -
PMJ88_RS14020 (PMJ88_14020) 2929255..2929725 + 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
PMJ88_RS14025 (PMJ88_14025) 2929722..2930297 + 576 WP_003153636.1 PIN domain-containing protein Toxin
PMJ88_RS14030 (PMJ88_14030) 2930315..2931229 + 915 WP_016852809.1 AAA family ATPase -
PMJ88_RS14035 (PMJ88_14035) 2931226..2931696 + 471 WP_003090160.1 type III CBASS phage resistance system CD-NTase-associated protein Cap8 -
PMJ88_RS14040 (PMJ88_14040) 2931693..2932193 + 501 WP_003090159.1 type III CBASS phage resistance system CD-NTase-associated protein Cap7 -
PMJ88_RS14045 (PMJ88_14045) 2932193..2933095 + 903 WP_003090158.1 CBASS oligonucleotide cyclase -
PMJ88_RS14050 (PMJ88_14050) 2933134..2933859 + 726 WP_003050273.1 CBASS effector endonuclease NucC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21629.78 Da        Isoelectric Point: 5.9995

>T269205 WP_003153636.1 NZ_CP116725:2929722-2930297 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT269205 WP_003050245.1 NZ_CP116725:2929255-2929725 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References