Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2634420..2634936 Replicon chromosome
Accession NZ_CP116725
Organism Pseudomonas aeruginosa strain 2881

Toxin (Protein)


Gene name relE Uniprot ID A0A3R8UIH5
Locus tag PMJ88_RS12680 Protein ID WP_025297453.1
Coordinates 2634655..2634936 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3R8UIM7
Locus tag PMJ88_RS12675 Protein ID WP_025297454.1
Coordinates 2634420..2634665 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ88_RS12655 (PMJ88_12655) 2629542..2629871 - 330 WP_031692728.1 hypothetical protein -
PMJ88_RS12660 (PMJ88_12660) 2630219..2630887 + 669 WP_071534660.1 hypothetical protein -
PMJ88_RS12665 (PMJ88_12665) 2630884..2631990 + 1107 WP_025297456.1 XRE family transcriptional regulator -
PMJ88_RS12670 (PMJ88_12670) 2632121..2634262 + 2142 WP_025297455.1 hypothetical protein -
PMJ88_RS12675 (PMJ88_12675) 2634420..2634665 + 246 WP_025297454.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
PMJ88_RS12680 (PMJ88_12680) 2634655..2634936 + 282 WP_025297453.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PMJ88_RS12685 (PMJ88_12685) 2635342..2635923 - 582 WP_033895412.1 plasmid pRiA4b ORF-3 family protein -
PMJ88_RS12690 (PMJ88_12690) 2635937..2636812 - 876 WP_033895413.1 WYL domain-containing protein -
PMJ88_RS12695 (PMJ88_12695) 2636941..2638521 + 1581 WP_063837559.1 DNA recombination protein RmuC -
PMJ88_RS12700 (PMJ88_12700) 2638545..2638937 + 393 WP_227274803.1 hypothetical protein -
PMJ88_RS12705 (PMJ88_12705) 2638921..2639193 + 273 WP_227274804.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2620171..2687318 67147


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-71)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10824.61 Da        Isoelectric Point: 10.6249

>T269204 WP_025297453.1 NZ_CP116725:2634655-2634936 [Pseudomonas aeruginosa]
MTYELEFLPSALKEWQKLGHTVREQIKKKLRERLDNPKVQADALRDMPGHYKIKLRASGYRLVYRVEDERVVVVVVAVGK
RERGAAYQSAKGR

Download         Length: 282 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8797.21 Da        Isoelectric Point: 4.2550

>AT269204 WP_025297454.1 NZ_CP116725:2634420-2634665 [Pseudomonas aeruginosa]
MQSILADVAVSVSELKKNPSGILAGAGGMPVAVLNHNRVMGYMVPAELYEQMMERLDDLELVEIVKARSGEESVPVRLDD
L

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R8UIH5

Antitoxin

Source ID Structure
AlphaFold DB A0A3R8UIM7

References