Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/HicA-HicB |
Location | 5640177..5640791 | Replicon | chromosome |
Accession | NZ_CP116724 | ||
Organism | Pseudomonas aeruginosa strain 2880 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | A6VBH9 |
Locus tag | PMJ92_RS26655 | Protein ID | WP_071534354.1 |
Coordinates | 5640609..5640791 (-) | Length | 61 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | A0A140SDX7 |
Locus tag | PMJ92_RS26650 | Protein ID | WP_012077229.1 |
Coordinates | 5640177..5640581 (-) | Length | 135 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
PMJ92_RS26625 (PMJ92_26625) | 5636317..5637027 | + | 711 | WP_012074129.1 | hypothetical protein | - |
PMJ92_RS26630 (PMJ92_26630) | 5637024..5637944 | + | 921 | WP_012074128.1 | hypothetical protein | - |
PMJ92_RS26635 (PMJ92_26635) | 5637941..5638480 | + | 540 | WP_012074127.1 | hypothetical protein | - |
PMJ92_RS26640 (PMJ92_26640) | 5638480..5639178 | + | 699 | WP_033896049.1 | hypothetical protein | - |
PMJ92_RS26645 (PMJ92_26645) | 5639163..5640134 | + | 972 | WP_012077228.1 | hypothetical protein | - |
PMJ92_RS26650 (PMJ92_26650) | 5640177..5640581 | - | 405 | WP_012077229.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
PMJ92_RS26655 (PMJ92_26655) | 5640609..5640791 | - | 183 | WP_071534354.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
PMJ92_RS26660 (PMJ92_26660) | 5641334..5642266 | - | 933 | WP_003120918.1 | ZIP family metal transporter | - |
PMJ92_RS26665 (PMJ92_26665) | 5642285..5642896 | - | 612 | WP_003098862.1 | superoxide dismutase | - |
PMJ92_RS26670 (PMJ92_26670) | 5642909..5643358 | - | 450 | WP_003094369.1 | hypothetical protein | - |
PMJ92_RS26675 (PMJ92_26675) | 5643386..5644762 | - | 1377 | WP_003098863.1 | class II fumarate hydratase FumC | - |
PMJ92_RS26680 (PMJ92_26680) | 5644755..5645150 | - | 396 | WP_003162782.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 5607134..5640791 | 33657 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6702.74 Da Isoelectric Point: 10.4826
>T269200 WP_071534354.1 NZ_CP116724:c5640791-5640609 [Pseudomonas aeruginosa]
MRSREVIDLLLEDGWYEVAVKGSHHQFKHPSKPGKVTVQHPSSTIPKGTLNNILKQAGLK
MRSREVIDLLLEDGWYEVAVKGSHHQFKHPSKPGKVTVQHPSSTIPKGTLNNILKQAGLK
Download Length: 183 bp
Antitoxin
Download Length: 135 a.a. Molecular weight: 14670.54 Da Isoelectric Point: 4.4315
>AT269200 WP_012077229.1 NZ_CP116724:c5640581-5640177 [Pseudomonas aeruginosa]
MKFPVVLHKDPDSDYGVTVPDVPGCFSAGATVSEALANVEEALALHFEGLVTDGEELPQPQDVDAHMKNPDFEGGVWAVV
DFDVTPYLGKAVRFNATLPEHLLQRIDERVKVDKRYQSRSGFLATAAMRELSVA
MKFPVVLHKDPDSDYGVTVPDVPGCFSAGATVSEALANVEEALALHFEGLVTDGEELPQPQDVDAHMKNPDFEGGVWAVV
DFDVTPYLGKAVRFNATLPEHLLQRIDERVKVDKRYQSRSGFLATAAMRELSVA
Download Length: 405 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A6VBH9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A140SDX7 |