Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2363996..2364691 Replicon chromosome
Accession NC_017524
Organism Mycobacterium tuberculosis CTRI-2

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag MTCTRI2_RS11055 Protein ID WP_003410811.1
Coordinates 2363996..2364430 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag MTCTRI2_RS11060 Protein ID WP_003410814.1
Coordinates 2364437..2364691 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTCTRI2_RS11045 2360230..2363191 + 2962 Protein_2166 DEAD/DEAH box helicase -
MTCTRI2_RS11050 2363184..2364017 + 834 WP_003899172.1 SWIM zinc finger family protein -
MTCTRI2_RS11055 2363996..2364430 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
MTCTRI2_RS11060 2364437..2364691 - 255 WP_003410814.1 antitoxin Antitoxin
MTCTRI2_RS11065 2364707..2364964 - 258 WP_003410816.1 hypothetical protein -
MTCTRI2_RS11070 2365911..2366207 + 297 WP_003410820.1 PE family protein -
MTCTRI2_RS11075 2366263..2366994 + 732 WP_003900467.1 PPE family protein -
MTCTRI2_RS11080 2367534..2368280 - 747 WP_003906749.1 proteasome subunit alpha -
MTCTRI2_RS11085 2368277..2369152 - 876 WP_003411023.1 proteasome subunit beta -
MTCTRI2_RS11090 2369149..2369343 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T26920 WP_003410811.1 NC_017524:c2364430-2363996 [Mycobacterium tuberculosis CTRI-2]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T26920 NC_017524:c2364430-2363996 [Mycobacterium tuberculosis CTRI-2]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT26920 WP_003410814.1 NC_017524:c2364691-2364437 [Mycobacterium tuberculosis CTRI-2]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT26920 NC_017524:c2364691-2364437 [Mycobacterium tuberculosis CTRI-2]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References