Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4997082..4998340 Replicon chromosome
Accession NZ_CP116724
Organism Pseudomonas aeruginosa strain 2880

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag PMJ92_RS23550 Protein ID WP_003086331.1
Coordinates 4997082..4997837 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PMJ92_RS23555 Protein ID WP_003086329.1
Coordinates 4997972..4998340 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ92_RS23540 (PMJ92_23540) 4992253..4994796 + 2544 WP_033955245.1 acyl-homoserine-lactone acylase QuiP -
PMJ92_RS23545 (PMJ92_23545) 4994952..4996313 - 1362 WP_003120632.1 DNA recombination protein RmuC -
PMJ92_RS23550 (PMJ92_23550) 4997082..4997837 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
PMJ92_RS23555 (PMJ92_23555) 4997972..4998340 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PMJ92_RS23560 (PMJ92_23560) 4998413..4999699 - 1287 WP_003086327.1 FAD-binding oxidoreductase -
PMJ92_RS23565 (PMJ92_23565) 4999755..5001344 - 1590 WP_023464367.1 aldehyde dehydrogenase family protein -
PMJ92_RS23570 (PMJ92_23570) 5001423..5001899 + 477 WP_004353334.1 elongation factor GreAB -
PMJ92_RS23575 (PMJ92_23575) 5001902..5002177 - 276 WP_023088486.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T269199 WP_003086331.1 NZ_CP116724:c4997837-4997082 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT269199 WP_003086329.1 NZ_CP116724:c4998340-4997972 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References