Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 4034475..4035696 Replicon chromosome
Accession NZ_CP116724
Organism Pseudomonas aeruginosa strain 2880

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag PMJ92_RS18980 Protein ID WP_003110488.1
Coordinates 4035118..4035696 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PMJ92_RS18975 Protein ID WP_003088112.1
Coordinates 4034475..4035029 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ92_RS18950 (PMJ92_18950) 4030043..4030594 + 552 WP_003450159.1 XRE family transcriptional regulator -
PMJ92_RS18955 (PMJ92_18955) 4030591..4030989 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
PMJ92_RS18960 (PMJ92_18960) 4031002..4031325 - 324 WP_015648646.1 multidrug efflux SMR transporter -
PMJ92_RS18965 (PMJ92_18965) 4031656..4032117 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
PMJ92_RS18970 (PMJ92_18970) 4032122..4034317 + 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PMJ92_RS18975 (PMJ92_18975) 4034475..4035029 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
PMJ92_RS18980 (PMJ92_18980) 4035118..4035696 + 579 WP_003110488.1 HD domain-containing protein Toxin
PMJ92_RS18985 (PMJ92_18985) 4035805..4036992 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
PMJ92_RS18990 (PMJ92_18990) 4036982..4039153 - 2172 WP_025297367.1 type I secretion system permease/ATPase -
PMJ92_RS18995 (PMJ92_18995) 4039143..4040420 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T269198 WP_003110488.1 NZ_CP116724:4035118-4035696 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT269198 WP_003088112.1 NZ_CP116724:4034475-4035029 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References