Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/- |
Location | 4034475..4035696 | Replicon | chromosome |
Accession | NZ_CP116724 | ||
Organism | Pseudomonas aeruginosa strain 2880 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A0H2Z8V4 |
Locus tag | PMJ92_RS18980 | Protein ID | WP_003110488.1 |
Coordinates | 4035118..4035696 (+) | Length | 193 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | - |
Locus tag | PMJ92_RS18975 | Protein ID | WP_003088112.1 |
Coordinates | 4034475..4035029 (+) | Length | 185 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
PMJ92_RS18950 (PMJ92_18950) | 4030043..4030594 | + | 552 | WP_003450159.1 | XRE family transcriptional regulator | - |
PMJ92_RS18955 (PMJ92_18955) | 4030591..4030989 | - | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
PMJ92_RS18960 (PMJ92_18960) | 4031002..4031325 | - | 324 | WP_015648646.1 | multidrug efflux SMR transporter | - |
PMJ92_RS18965 (PMJ92_18965) | 4031656..4032117 | + | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
PMJ92_RS18970 (PMJ92_18970) | 4032122..4034317 | + | 2196 | WP_003122807.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
PMJ92_RS18975 (PMJ92_18975) | 4034475..4035029 | + | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
PMJ92_RS18980 (PMJ92_18980) | 4035118..4035696 | + | 579 | WP_003110488.1 | HD domain-containing protein | Toxin |
PMJ92_RS18985 (PMJ92_18985) | 4035805..4036992 | - | 1188 | WP_003102741.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
PMJ92_RS18990 (PMJ92_18990) | 4036982..4039153 | - | 2172 | WP_025297367.1 | type I secretion system permease/ATPase | - |
PMJ92_RS18995 (PMJ92_18995) | 4039143..4040420 | - | 1278 | WP_003102743.1 | TolC family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21913.75 Da Isoelectric Point: 5.3655
>T269198 WP_003110488.1 NZ_CP116724:4035118-4035696 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT269198 WP_003088112.1 NZ_CP116724:4034475-4035029 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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