Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2730993..2731509 Replicon chromosome
Accession NZ_CP116724
Organism Pseudomonas aeruginosa strain 2880

Toxin (Protein)


Gene name relE Uniprot ID A0A3R8UIH5
Locus tag PMJ92_RS13085 Protein ID WP_025297453.1
Coordinates 2731228..2731509 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3R8UIM7
Locus tag PMJ92_RS13080 Protein ID WP_025297454.1
Coordinates 2730993..2731238 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ92_RS13060 (PMJ92_13060) 2726115..2726444 - 330 WP_031692728.1 hypothetical protein -
PMJ92_RS13065 (PMJ92_13065) 2726792..2727460 + 669 WP_071534660.1 hypothetical protein -
PMJ92_RS13070 (PMJ92_13070) 2727457..2728563 + 1107 WP_025297456.1 XRE family transcriptional regulator -
PMJ92_RS13075 (PMJ92_13075) 2728694..2730835 + 2142 WP_025297455.1 hypothetical protein -
PMJ92_RS13080 (PMJ92_13080) 2730993..2731238 + 246 WP_025297454.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
PMJ92_RS13085 (PMJ92_13085) 2731228..2731509 + 282 WP_025297453.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PMJ92_RS13090 (PMJ92_13090) 2731915..2732496 - 582 WP_033895412.1 plasmid pRiA4b ORF-3 family protein -
PMJ92_RS13095 (PMJ92_13095) 2732510..2733385 - 876 WP_033895413.1 WYL domain-containing protein -
PMJ92_RS13100 (PMJ92_13100) 2733514..2735094 + 1581 WP_063837559.1 DNA recombination protein RmuC -
PMJ92_RS13105 (PMJ92_13105) 2735118..2735510 + 393 WP_227274803.1 hypothetical protein -
PMJ92_RS13110 (PMJ92_13110) 2735494..2735766 + 273 WP_227274804.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2716744..2781523 64779


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-71)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10824.61 Da        Isoelectric Point: 10.6249

>T269197 WP_025297453.1 NZ_CP116724:2731228-2731509 [Pseudomonas aeruginosa]
MTYELEFLPSALKEWQKLGHTVREQIKKKLRERLDNPKVQADALRDMPGHYKIKLRASGYRLVYRVEDERVVVVVVAVGK
RERGAAYQSAKGR

Download         Length: 282 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8797.21 Da        Isoelectric Point: 4.2550

>AT269197 WP_025297454.1 NZ_CP116724:2730993-2731238 [Pseudomonas aeruginosa]
MQSILADVAVSVSELKKNPSGILAGAGGMPVAVLNHNRVMGYMVPAELYEQMMERLDDLELVEIVKARSGEESVPVRLDD
L

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R8UIH5

Antitoxin

Source ID Structure
AlphaFold DB A0A3R8UIM7

References