Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 2023129..2024637 Replicon chromosome
Accession NZ_CP116724
Organism Pseudomonas aeruginosa strain 2880

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag PMJ92_RS09465 Protein ID WP_003119682.1
Coordinates 2023129..2023716 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A6V2F0
Locus tag PMJ92_RS09470 Protein ID WP_012074952.1
Coordinates 2023783..2024637 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ92_RS09460 (PMJ92_09460) 2019384..2022863 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
PMJ92_RS09465 (PMJ92_09465) 2023129..2023716 + 588 WP_003119682.1 GNAT family protein Toxin
PMJ92_RS09470 (PMJ92_09470) 2023783..2024637 + 855 WP_012074952.1 AraC family transcriptional regulator Antitoxin
PMJ92_RS09475 (PMJ92_09475) 2024733..2026898 + 2166 WP_025297505.1 TonB-dependent receptor family protein -
PMJ92_RS09480 (PMJ92_09480) 2027073..2028947 + 1875 WP_003117607.1 MFS transporter -
PMJ92_RS09485 (PMJ92_09485) 2029008..2029217 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

DNA binding HTH domain, AraC-type

(196-273)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T269195 WP_003119682.1 NZ_CP116724:2023129-2023716 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31788.11 Da        Isoelectric Point: 7.7066

>AT269195 WP_012074952.1 NZ_CP116724:2023783-2024637 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSGFALVFIEQGAQRFRHRGGEHLAPWGSMVLINPDEVHTGSK
AHDSGWLYRGYYPEVEQIASILDELEIRHGGVPRFADSVVHDQPLARAFVHLHRLLADHAGSLETQTCWRETLLALFRRH
ARLPEAPKAGSEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKNGRA
PLDVALELGFADQSHLGRQFKQAYGVAPGEYRAACARSSLTMCE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A6V2F0

References