Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 5093653..5094911 Replicon chromosome
Accession NZ_CP116722
Organism Pseudomonas aeruginosa strain 2868

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag PMJ90_RS24235 Protein ID WP_003086331.1
Coordinates 5093653..5094408 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PMJ90_RS24240 Protein ID WP_003086329.1
Coordinates 5094543..5094911 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ90_RS24225 (PMJ90_24225) 5088824..5091367 + 2544 WP_033955245.1 acyl-homoserine-lactone acylase QuiP -
PMJ90_RS24230 (PMJ90_24230) 5091523..5092884 - 1362 WP_003120632.1 DNA recombination protein RmuC -
PMJ90_RS24235 (PMJ90_24235) 5093653..5094408 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
PMJ90_RS24240 (PMJ90_24240) 5094543..5094911 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PMJ90_RS24245 (PMJ90_24245) 5094984..5096270 - 1287 WP_003086327.1 FAD-binding oxidoreductase -
PMJ90_RS24250 (PMJ90_24250) 5096326..5097915 - 1590 WP_023464367.1 aldehyde dehydrogenase family protein -
PMJ90_RS24255 (PMJ90_24255) 5097994..5098470 + 477 WP_004353334.1 elongation factor GreAB -
PMJ90_RS24260 (PMJ90_24260) 5098473..5098748 - 276 WP_023088486.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T269192 WP_003086331.1 NZ_CP116722:c5094408-5093653 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT269192 WP_003086329.1 NZ_CP116722:c5094911-5094543 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References