Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 4072444..4073665 Replicon chromosome
Accession NZ_CP116722
Organism Pseudomonas aeruginosa strain 2868

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag PMJ90_RS19180 Protein ID WP_003110488.1
Coordinates 4073087..4073665 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PMJ90_RS19175 Protein ID WP_003088112.1
Coordinates 4072444..4072998 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ90_RS19150 (PMJ90_19150) 4068012..4068563 + 552 WP_003450159.1 XRE family transcriptional regulator -
PMJ90_RS19155 (PMJ90_19155) 4068560..4068958 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
PMJ90_RS19160 (PMJ90_19160) 4068971..4069294 - 324 WP_015648646.1 multidrug efflux SMR transporter -
PMJ90_RS19165 (PMJ90_19165) 4069625..4070086 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
PMJ90_RS19170 (PMJ90_19170) 4070091..4072286 + 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PMJ90_RS19175 (PMJ90_19175) 4072444..4072998 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
PMJ90_RS19180 (PMJ90_19180) 4073087..4073665 + 579 WP_003110488.1 HD domain-containing protein Toxin
PMJ90_RS19185 (PMJ90_19185) 4073774..4074961 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
PMJ90_RS19190 (PMJ90_19190) 4074951..4077122 - 2172 WP_025297367.1 type I secretion system permease/ATPase -
PMJ90_RS19195 (PMJ90_19195) 4077112..4078389 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T269191 WP_003110488.1 NZ_CP116722:4073087-4073665 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT269191 WP_003088112.1 NZ_CP116722:4072444-4072998 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References