Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2980782..2981824 Replicon chromosome
Accession NZ_CP116722
Organism Pseudomonas aeruginosa strain 2868

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag PMJ90_RS14225 Protein ID WP_003153636.1
Coordinates 2981249..2981824 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag PMJ90_RS14220 Protein ID WP_003050245.1
Coordinates 2980782..2981252 (+) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ90_RS14185 (PMJ90_14185) 2976174..2977592 - 1419 WP_006226029.1 TIGR03752 family integrating conjugative element protein -
PMJ90_RS14190 (PMJ90_14190) 2977582..2978493 - 912 WP_006226028.1 TIGR03749 family integrating conjugative element protein -
PMJ90_RS14195 (PMJ90_14195) 2978490..2979182 - 693 WP_003090182.1 TIGR03746 family integrating conjugative element protein -
PMJ90_RS14200 (PMJ90_14200) 2979179..2979577 - 399 WP_003050133.1 TIGR03750 family conjugal transfer protein -
PMJ90_RS14205 (PMJ90_14205) 2979589..2979948 - 360 WP_003090173.1 TIGR03745 family integrating conjugative element membrane protein -
PMJ90_RS14210 (PMJ90_14210) 2979965..2980198 - 234 WP_023101201.1 TIGR03758 family integrating conjugative element protein -
PMJ90_RS14215 (PMJ90_14215) 2980195..2980578 - 384 WP_003090167.1 RAQPRD family integrative conjugative element protein -
PMJ90_RS14220 (PMJ90_14220) 2980782..2981252 + 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
PMJ90_RS14225 (PMJ90_14225) 2981249..2981824 + 576 WP_003153636.1 PIN domain-containing protein Toxin
PMJ90_RS14230 (PMJ90_14230) 2981842..2982756 + 915 WP_016852809.1 AAA family ATPase -
PMJ90_RS14235 (PMJ90_14235) 2982753..2983223 + 471 WP_003090160.1 type III CBASS phage resistance system CD-NTase-associated protein Cap8 -
PMJ90_RS14240 (PMJ90_14240) 2983220..2983720 + 501 WP_003090159.1 type III CBASS phage resistance system CD-NTase-associated protein Cap7 -
PMJ90_RS14245 (PMJ90_14245) 2983720..2984622 + 903 WP_003090158.1 CBASS oligonucleotide cyclase -
PMJ90_RS14250 (PMJ90_14250) 2984661..2985386 + 726 WP_003050273.1 CBASS effector endonuclease NucC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21629.78 Da        Isoelectric Point: 5.9995

>T269190 WP_003153636.1 NZ_CP116722:2981249-2981824 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT269190 WP_003050245.1 NZ_CP116722:2980782-2981252 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References