Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2688820..2689336 Replicon chromosome
Accession NZ_CP116722
Organism Pseudomonas aeruginosa strain 2868

Toxin (Protein)


Gene name relE Uniprot ID A0A3R8UIH5
Locus tag PMJ90_RS12915 Protein ID WP_025297453.1
Coordinates 2689055..2689336 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3R8UIM7
Locus tag PMJ90_RS12910 Protein ID WP_025297454.1
Coordinates 2688820..2689065 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ90_RS12890 (PMJ90_12890) 2683942..2684271 - 330 WP_031692728.1 hypothetical protein -
PMJ90_RS12895 (PMJ90_12895) 2684619..2685287 + 669 WP_071534660.1 hypothetical protein -
PMJ90_RS12900 (PMJ90_12900) 2685284..2686390 + 1107 WP_025297456.1 XRE family transcriptional regulator -
PMJ90_RS12905 (PMJ90_12905) 2686521..2688662 + 2142 WP_025297455.1 hypothetical protein -
PMJ90_RS12910 (PMJ90_12910) 2688820..2689065 + 246 WP_025297454.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
PMJ90_RS12915 (PMJ90_12915) 2689055..2689336 + 282 WP_025297453.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PMJ90_RS12920 (PMJ90_12920) 2689742..2690323 - 582 WP_033895412.1 plasmid pRiA4b ORF-3 family protein -
PMJ90_RS12925 (PMJ90_12925) 2690337..2691212 - 876 WP_033895413.1 WYL domain-containing protein -
PMJ90_RS12930 (PMJ90_12930) 2691341..2692921 + 1581 WP_063837559.1 DNA recombination protein RmuC -
PMJ90_RS12935 (PMJ90_12935) 2692945..2693337 + 393 WP_227274803.1 hypothetical protein -
PMJ90_RS12940 (PMJ90_12940) 2693321..2693593 + 273 WP_227274804.1 hypothetical protein -
PMJ90_RS12945 (PMJ90_12945) 2693757..2693888 + 132 WP_272218011.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2672055..2739265 67210


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-71)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10824.61 Da        Isoelectric Point: 10.6249

>T269189 WP_025297453.1 NZ_CP116722:2689055-2689336 [Pseudomonas aeruginosa]
MTYELEFLPSALKEWQKLGHTVREQIKKKLRERLDNPKVQADALRDMPGHYKIKLRASGYRLVYRVEDERVVVVVVAVGK
RERGAAYQSAKGR

Download         Length: 282 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8797.21 Da        Isoelectric Point: 4.2550

>AT269189 WP_025297454.1 NZ_CP116722:2688820-2689065 [Pseudomonas aeruginosa]
MQSILADVAVSVSELKKNPSGILAGAGGMPVAVLNHNRVMGYMVPAELYEQMMERLDDLELVEIVKARSGEESVPVRLDD
L

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R8UIH5

Antitoxin

Source ID Structure
AlphaFold DB A0A3R8UIM7

References