Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 162384..162889 Replicon chromosome
Accession NZ_CP116722
Organism Pseudomonas aeruginosa strain 2868

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag PMJ90_RS00790 Protein ID WP_003083773.1
Coordinates 162384..162665 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag PMJ90_RS00795 Protein ID WP_003083775.1
Coordinates 162662..162889 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ90_RS00765 (PMJ90_00765) 157635..158984 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
PMJ90_RS00770 (PMJ90_00770) 159033..159719 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
PMJ90_RS00775 (PMJ90_00775) 159820..160554 + 735 WP_004346926.1 GntR family transcriptional regulator -
PMJ90_RS00780 (PMJ90_00780) 160734..161144 + 411 WP_003101225.1 aegerolysin family protein -
PMJ90_RS00785 (PMJ90_00785) 161176..162084 - 909 WP_003083769.1 LysR family transcriptional regulator -
PMJ90_RS00790 (PMJ90_00790) 162384..162665 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
PMJ90_RS00795 (PMJ90_00795) 162662..162889 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
PMJ90_RS00800 (PMJ90_00800) 163065..163685 - 621 WP_003101226.1 hypothetical protein -
PMJ90_RS00805 (PMJ90_00805) 163786..164286 + 501 WP_003101228.1 LEA type 2 family protein -
PMJ90_RS00810 (PMJ90_00810) 164359..164700 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
PMJ90_RS00815 (PMJ90_00815) 164782..166209 - 1428 WP_003083784.1 GABA permease -
PMJ90_RS00820 (PMJ90_00820) 166378..167871 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T269187 WP_003083773.1 NZ_CP116722:c162665-162384 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT269187 WP_003083775.1 NZ_CP116722:c162889-162662 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References