Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4921963..4923221 Replicon chromosome
Accession NZ_CP116721
Organism Pseudomonas aeruginosa strain 2867

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag PMJ93_RS23080 Protein ID WP_003086331.1
Coordinates 4921963..4922718 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PMJ93_RS23085 Protein ID WP_003086329.1
Coordinates 4922853..4923221 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMJ93_RS23070 (PMJ93_23070) 4917134..4919677 + 2544 WP_033955245.1 acyl-homoserine-lactone acylase QuiP -
PMJ93_RS23075 (PMJ93_23075) 4919833..4921194 - 1362 WP_003120632.1 DNA recombination protein RmuC -
PMJ93_RS23080 (PMJ93_23080) 4921963..4922718 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
PMJ93_RS23085 (PMJ93_23085) 4922853..4923221 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PMJ93_RS23090 (PMJ93_23090) 4923294..4924580 - 1287 WP_003086327.1 FAD-binding oxidoreductase -
PMJ93_RS23095 (PMJ93_23095) 4924636..4926225 - 1590 WP_023464367.1 aldehyde dehydrogenase family protein -
PMJ93_RS23100 (PMJ93_23100) 4926304..4926780 + 477 WP_004353334.1 elongation factor GreAB -
PMJ93_RS23105 (PMJ93_23105) 4926783..4927058 - 276 WP_023088486.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T269184 WP_003086331.1 NZ_CP116721:c4922718-4921963 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT269184 WP_003086329.1 NZ_CP116721:c4923221-4922853 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References